NRF2-mediated Oxidative Stress Response
Oxidative stress is caused by an imbalance between the production of reactive oxygen and the detoxification of reactive intermediates. Reactive intermediates such as peroxides and free radicals can be very damaging to many parts of cells such as proteins, lipids and DNA. Severe oxidative stress can trigger apoptosis and necrosis. Oxidative stress is involved in many diseases such as atherosclerosis, Parkinson's disease and Alzheimer's disease. Oxidative stress has also been linked to aging...
Pathway Summary
Oxidative stress is caused by an imbalance between the production of reactive oxygen and the detoxification of reactive intermediates. Reactive intermediates such as peroxides and free radicals can be very damaging to many parts of cells such as proteins, lipids and DNA. Severe oxidative stress can trigger apoptosis and necrosis. Oxidative stress is involved in many diseases such as atherosclerosis, Parkinson's disease and Alzheimer's disease. Oxidative stress has also been linked to aging. The cellular defense response to oxidative stress includes induction of detoxifying enzymes and antioxidant enzymes. Nuclear factor-erythroid 2-related factor 2 (Nrf2) binds to the antioxidant response elements (ARE) within the promoter of these enzymes and activates their transcription. Inactive Nrf2 is retained in the cytoplasm by association with an actin-binding protein Keap1. Upon exposure of cells to oxidative stress, Nrf2 is phosphorylated in response to the protein kinase C, phosphatidylinositol 3-kinase and MAP kinase pathways. After phosphorylation, Nrf2 translocates to the nucleus, binds AREs and transactivates detoxifying enzymes and antioxidant enzymes, such as glutathione S-transferase, cytochrome P450, NAD(P)H quinone oxidoreductase, heme oxygenase and superoxide dismutase.
NRF2-mediated Oxidative Stress Response Genes list
Explore Genes related to NRF2-mediated Oxidative Stress Response
ABCC1ATP binding cassette subfamily C member 1 ABCC2ATP binding cassette subfamily C member 2 ABCC4ATP binding cassette subfamily C member 4 ACTA1actin alpha 1, skeletal muscle ACTA2actin alpha 2, smooth muscle ACTBactin beta ACTC1actin alpha cardiac muscle 1 ACTG1actin gamma 1 ACTG2actin gamma 2, smooth muscle AKR1A1aldo-keto reductase family 1 member A1 AKR7A2aldo-keto reductase family 7 member A2 AKR7A3aldo-keto reductase family 7 member A3 AKT1AKT serine/threonine kinase 1 AOX1aldehyde oxidase 1 ATF4activating transcription factor 4 BACH1BTB domain and CNC homolog 1 CATcatalase CBR1carbonyl reductase 1 CCT7chaperonin containing TCP1 subunit 7 CDC34cell division cycle 34, ubiqiutin conjugating enzyme CLPPcaseinolytic mitochondrial matrix peptidase proteolytic subunit CREBBPCREB binding protein CUL3cullin 3 CYP1A1cytochrome P450 family 1 subfamily A member 1 CYP1A2cytochrome P450 family 1 subfamily A member 2 CYP2B6cytochrome P450 family 2 subfamily B member 6 CYP2C18cytochrome P450 family 2 subfamily C member 18 CYP2C19cytochrome P450 family 2 subfamily C member 19 CYP2C8cytochrome P450 family 2 subfamily C member 8 CYP2C9cytochrome P450 family 2 subfamily C member 9 CYP2D6cytochrome P450 family 2 subfamily D member 6 CYP2E1cytochrome P450 family 2 subfamily E member 1 CYP2F1cytochrome P450 family 2 subfamily F member 1 CYP2J2cytochrome P450 family 2 subfamily J member 2 CYP2R1cytochrome P450 family 2 subfamily R member 1 CYP2S1cytochrome P450 family 2 subfamily S member 1 CYP2U1cytochrome P450 family 2 subfamily U member 1 CYP3A4cytochrome P450 family 3 subfamily A member 4 CYP3A43cytochrome P450 family 3 subfamily A member 43 CYP3A5cytochrome P450 family 3 subfamily A member 5 CYP3A7cytochrome P450 family 3 subfamily A member 7 CYP4A11cytochrome P450 family 4 subfamily A member 11 CYP4A22cytochrome P450 family 4 subfamily A member 22 CYP4Z1cytochrome P450 family 4 subfamily Z member 1 DNAJA1DnaJ heat shock protein family (Hsp40) member A1 DNAJA2DnaJ heat shock protein family (Hsp40) member A2 DNAJA3DnaJ heat shock protein family (Hsp40) member A3 DNAJA4DnaJ heat shock protein family (Hsp40) member A4 DNAJB1DnaJ heat shock protein family (Hsp40) member B1 DNAJB11DnaJ heat shock protein family (Hsp40) member B11 DNAJB12DnaJ heat shock protein family (Hsp40) member B12 DNAJB13DnaJ heat shock protein family (Hsp40) member B13 DNAJB14DnaJ heat shock protein family (Hsp40) member B14 DNAJB2DnaJ heat shock protein family (Hsp40) member B2 DNAJB4DnaJ heat shock protein family (Hsp40) member B4 DNAJB5DnaJ heat shock protein family (Hsp40) member B5 DNAJB6DnaJ heat shock protein family (Hsp40) member B6 DNAJB7DnaJ heat shock protein family (Hsp40) member B7 DNAJB8DnaJ heat shock protein family (Hsp40) member B8 DNAJB9DnaJ heat shock protein family (Hsp40) member B9 DNAJC1DnaJ heat shock protein family (Hsp40) member C1 DNAJC10DnaJ heat shock protein family (Hsp40) member C10 DNAJC11DnaJ heat shock protein family (Hsp40) member C11 DNAJC12DnaJ heat shock protein family (Hsp40) member C12 DNAJC13DnaJ heat shock protein family (Hsp40) member C13 DNAJC14DnaJ heat shock protein family (Hsp40) member C14 DNAJC15DnaJ heat shock protein family (Hsp40) member C15 DNAJC16DnaJ heat shock protein family (Hsp40) member C16 DNAJC17DnaJ heat shock protein family (Hsp40) member C17 DNAJC18DnaJ heat shock protein family (Hsp40) member C18 DNAJC19DnaJ heat shock protein family (Hsp40) member C19 DNAJC21DnaJ heat shock protein family (Hsp40) member C21 DNAJC3DnaJ heat shock protein family (Hsp40) member C3 DNAJC4DnaJ heat shock protein family (Hsp40) member C4 DNAJC5DnaJ heat shock protein family (Hsp40) member C5 DNAJC5BDnaJ heat shock protein family (Hsp40) member C5 beta DNAJC5GDnaJ heat shock protein family (Hsp40) member C5 gamma DNAJC6DnaJ heat shock protein family (Hsp40) member C6 DNAJC7DnaJ heat shock protein family (Hsp40) member C7 DNAJC8DnaJ heat shock protein family (Hsp40) member C8 DNAJC9DnaJ heat shock protein family (Hsp40) member C9 EIF2AK3eukaryotic translation initiation factor 2 alpha kinase 3 ENC1ectodermal-neural cortex 1 EP300E1A binding protein p300 EPHX1epoxide hydrolase 1 ERASES cell expressed Ras ERP29endoplasmic reticulum protein 29 FKBP5FKBP prolyl isomerase 5 FMO1flavin containing dimethylaniline monoxygenase 1 FOSFos proto-oncogene, AP-1 transcription factor subunit FOSL1FOS like 1, AP-1 transcription factor subunit FTH1ferritin heavy chain 1 FTLferritin light chain GCLCglutamate-cysteine ligase catalytic subunit GCLMglutamate-cysteine ligase modifier subunit GPX2glutathione peroxidase 2 GSK3Bglycogen synthase kinase 3 beta GSRglutathione-disulfide reductase GSTA1glutathione S-transferase alpha 1 GSTA2glutathione S-transferase alpha 2 GSTA3glutathione S-transferase alpha 3 GSTA4glutathione S-transferase alpha 4 GSTA5glutathione S-transferase alpha 5 GSTK1glutathione S-transferase kappa 1 GSTM1glutathione S-transferase mu 1 GSTM2glutathione S-transferase mu 2 GSTM3glutathione S-transferase mu 3 GSTM4glutathione S-transferase mu 4 GSTM5glutathione S-transferase mu 5 GSTO1glutathione S-transferase omega 1 GSTO2glutathione S-transferase omega 2 GSTP1glutathione S-transferase pi 1 GSTT1glutathione S-transferase theta 1 GSTZ1glutathione S-transferase zeta 1 HACD33-hydroxyacyl-CoA dehydratase 3 HERPUD1homocysteine inducible ER protein with ubiquitin like domain 1 HMOX1heme oxygenase 1 HRASHRas proto-oncogene, GTPase HSP90AA1heat shock protein 90 alpha family class A member 1 HSP90AB1heat shock protein 90 alpha family class B member 1 HSP90B1heat shock protein 90 beta family member 1 HSPB8heat shock protein family B (small) member 8 JUNJun proto-oncogene, AP-1 transcription factor subunit JUNBJunB proto-oncogene, AP-1 transcription factor subunit JUNDJunD proto-oncogene, AP-1 transcription factor subunit KEAP1kelch like ECH associated protein 1 KRASKRAS proto-oncogene, GTPase MAFMAF bZIP transcription factor MAFFMAF bZIP transcription factor F MAFGMAF bZIP transcription factor G MAFKMAF bZIP transcription factor K MAP2K1mitogen-activated protein kinase kinase 1 MAP2K2mitogen-activated protein kinase kinase 2 MAP2K3mitogen-activated protein kinase kinase 3 MAP2K4mitogen-activated protein kinase kinase 4 MAP2K5mitogen-activated protein kinase kinase 5 MAP2K6mitogen-activated protein kinase kinase 6 MAP2K7mitogen-activated protein kinase kinase 7 MAP3K1mitogen-activated protein kinase kinase kinase 1 MAP3K5mitogen-activated protein kinase kinase kinase 5 MAP3K7mitogen-activated protein kinase kinase kinase 7 MAPK1mitogen-activated protein kinase 1 MAPK14mitogen-activated protein kinase 14 MAPK3mitogen-activated protein kinase 3 MAPK7mitogen-activated protein kinase 7 MAPK8mitogen-activated protein kinase 8 MAPK9mitogen-activated protein kinase 9 MGST1microsomal glutathione S-transferase 1 MGST2microsomal glutathione S-transferase 2 MGST3microsomal glutathione S-transferase 3 MRASmuscle RAS oncogene homolog NFE2L2nuclear factor, erythroid 2 like 2 NQO1NAD(P)H quinone dehydrogenase 1 NQO2N-ribosyldihydronicotinamide:quinone reductase 2 NRASNRAS proto-oncogene, GTPase PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha PIK3C2Bphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta PIK3C2Gphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma PIK3C3phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CBphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma PIK3R1phosphoinositide-3-kinase regulatory subunit 1 PIK3R2phosphoinositide-3-kinase regulatory subunit 2 PIK3R3phosphoinositide-3-kinase regulatory subunit 3 PIK3R4phosphoinositide-3-kinase regulatory subunit 4 PIK3R5phosphoinositide-3-kinase regulatory subunit 5 PIK3R6phosphoinositide-3-kinase regulatory subunit 6 PMF1polyamine modulated factor 1 PPIBpeptidylprolyl isomerase B PRDX1peroxiredoxin 1 PRKCAprotein kinase C alpha PRKCBprotein kinase C beta PRKCDprotein kinase C delta PRKCEprotein kinase C epsilon PRKCGprotein kinase C gamma PRKCHprotein kinase C eta PRKCIprotein kinase C iota PRKCQprotein kinase C theta PRKCZprotein kinase C zeta PRKD1protein kinase D1 PRKD3protein kinase D3 RAF1Raf-1 proto-oncogene, serine/threonine kinase RALARAS like proto-oncogene A RALBRAS like proto-oncogene B RAP1ARAP1A, member of RAS oncogene family RAP1BRAP1B, member of RAS oncogene family RAP2ARAP2A, member of RAS oncogene family RAP2BRAP2B, member of RAS oncogene family RASD1ras related dexamethasone induced 1 RASD2RASD family member 2 RBX1ring-box 1 RRASRAS related RRAS2RAS related 2 SCARB1scavenger receptor class B member 1 SLC35A2solute carrier family 35 member A2 SOD1superoxide dismutase 1 SOD2superoxide dismutase 2 SOD3superoxide dismutase 3 SQSTM1sequestosome 1 STIP1stress induced phosphoprotein 1 TXNthioredoxin TXNRD1thioredoxin reductase 1 UBBubiquitin B UBE2E3ubiquitin conjugating enzyme E2 E3 UBE2Kubiquitin conjugating enzyme E2 K USP14ubiquitin specific peptidase 14 VCPvalosin containing protein
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