GeneGlobe ID: PHS-3200Z | Cat. No.: | QIAseq Targeted DNA Pro Panels

QIAseq Targeted DNA Pro Human Comprehensive Hereditary Cancer Research Panel

Kit containing ALL reagents (except indexes) for targeted DNA sequencing

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Product Specification

Target List

Central Nervous System Cancers
Anaplastic Glial Tumors​
CDKN2A (P16INK4A), CDKN2B (p15INK4b), PTEN, RB1, TP53 (p53)
Astrocytomas​
APC, ATRX, BRAF, CDKN2A (P16INK4A), CDKN2B (p15INK4b), CDKN2B-AS1, CHEK2 (RAD53), FGFR1, HIPK2, HRAS, IDH1, MSH2, MYB, NF1, PALB2, PTPN11, RB1, SDHA, TP53 (p53), TSC1
Atypical Teratoid Rhabdoid Tumors​
SMARCA4, SMARCB1
Craniopharyngiomas​
BRAF, CTNNB1
Ependymomas​
CDKN2A (P16INK4A), ERBB2 (HER-2, NEU), MEN1, NF2, TP53 (p53)
Ganglioneuromas​
ALK, PHOX2B
Glioblastomas​
ALK, APC, BCOR, BRAF, BRCA2, CDK4, CDKN2A (P16INK4A), CDKN2B (p15INK4b), CREBBP (CBP), EGFR (ERBB1), EPCAM, ERBB2 (HER-2, NEU), IDH1, KIT (CD117), LZTR1, MLH1, MSH2, MSH6, MTOR, MYC, NRAS, PIK3CA (p110-alpha), PMS2, PTEN, RB1, TP53 (p53)
Gliomas​
ACVR1 (ALK2), ADGRB3, ATRX, BRAF, BRCA2, BRIP1, CDKN2A (P16INK4A), CHD2, CHEK2 (RAD53), CIC, EGFR (ERBB1), EP300, FGFR1, FLT1 (VEGFR1), H3-3A, IDH1, IRS2, MDM4, MYB, MYCN, NF1, NSD2, PDGFRA, PIK3CA (p110-alpha), POT1, PTEN, STYK1, TP53 (p53)
Hereditary Paraganglioma-Pheochromocytoma Syndrome​
MAX, SDHAF2, SDHB, SDHC, SDHD, TMEM127
Intercranial Ependymomas​
CDKN2A (P16INK4A), CDKN2B (p15INK4b)
Lynch Syndrome​
EPCAM, MLH1, MSH2, MSH6, PMS2
Medulloblastomas​
ALPK2, APC, BRCA2, CACNA1D, CDH1 (E-Cadherin), CDK4, CHD7, CLTCL1, CREBBP (CBP), CTCF, CTNNB1, DDX3X, DDX60, DEPDC5, DICER1, DNAH14, DYNC1H1, ERBB2 (HER-2, NEU), FAP, FCRL2, FGFR1, GABRG1, GPAM, HDAC9, IDH1, IFIT3, IRX2, KAT6A, KDM4C, KDM6A, KIF7, KMT2B, KMT2D, LRRK1, LRRK2, MAST4, MSH2, MYC, MYCN, NCAPD3, NLRP5, NRAS, NRP1, OTOF, OTX2, PARP2, PCDHGB3, PFKP, PIK3CA (p110-alpha), PRKAG2, PRLR, PTCH1, PTCH2, PTEN, RAB11FIP1, RB1, SF3B1, SMARCA4, SMARCB1, SUFU, TP53 (p53), TPO, TTN, WDFY3, WDFY4, WRN, ZMYM3
Meningiomas​
CDKN2A (P16INK4A), CDKN2B (p15INK4b), G6PD, MN1, NF2, PDGFB, PTEN, SMARCE1, SUFU
Neuroblastomas​
ALK, BRCA1, BRCA2, DICER1, EZH2, HRAS, KIF1B, NRAS, PHOX2B, PTCH1, PTPN11, SMARCA4, TP53 (p53)
Neurofibromas​
EPCAM, MLH1, MSH2, MSH6, NF1, PMS2
Neurofibromatosis​
NF1, NF2
Oligodendrogliomas​
CDKN2A (P16INK4A), CDKN2B (p15INK4b), IDH1, MSH2, RB1
Tuberous Sclerosis Complex​
TSC1, TSC2
Other Central Nervous System Cancer Genes​
AIP, CDKN1B (P27KIP1), EPHB2, PRKAR1A, VHL
Colorectal Cancers
Adenocarcinomas​
APC, ATM, AXIN2, BMPR1A (ALK3), BRAF, BRCA1, BRCA2, CHEK2 (RAD53), EP300, FLCN, MLH1, MLH3, MSH2, MSH3, MSH6, MUTYH, NRAS, PALB2, PMS1, PMS2, POLD1, POLE, PTEN, RNF43, SMAD4 (MADH4), STK11 (LKB1), TGFBR2, TP53 (p53)
Colorectal Cancer Susceptibility​
CCND1, GALNT12, POLD1, POLE, SMAD7
Familial Adenomatous Polyposis​
APC, MSH3, MUTYH, NTHL1, POLD1, POLE
Hereditary Mixed Polyposis Syndrome​
BMPR1A (ALK3), GREM1
Hereditary Nonpolyposis​
BRAF, EPCAM, MLH1, MLH3, MSH2, MSH6, PMS1, PMS2, TGFBR2
Hereditary Polyposis Syndrome​
BMPR1A (ALK3), GREM1
Juvenile Polyposis Syndrome​
BMPR1A (ALK3), SMAD4 (MADH4)
Lynch Syndrome​
BRAF, EPCAM, MLH1, MLH3, MSH2, MSH6, PMS1, PMS2, TGFBR2
Metastatic Colorectal Cancers​
ATM, BRAF, NRAS
Muir-Torre Syndrome​
MLH1, MSH2
Other Colorectal Cancer Genes​
AURKA, BLM, CDH1 (E-Cadherin), PKHD1, PLA2G2A, RB1, RPS20, SEMA4A, TLR2, XRCC2
Gastric Cancers
Gastrointestinal Stromal Tumors (GIST)​
KIT (CD117), NF1, PDGFRA, SDHB, SDHC, SDHD, TMEM127
Lynch Syndrome​
EPCAM, MLH1, MSH2, MSH6, PMS2
Multiple Endocrine Neoplasia​
CDKN1B (P27KIP1), MEN1
Other Gastric Cancer Genes​
APC, ATM, BMPR1A (ALK3), CDH1 (E-Cadherin), CHEK2 (RAD53), CTNNA1, KRAS, SMAD4 (MADH4), STK11 (LKB1), TP53 (p53)
Hematological Malignancies
Eosinophilia​
CR2, JAK1
Lymphoproliferative Disorders​
PLAA, SH2D1A, XIAP
Mastocytosis​
DNMT3A, IDH2, KIT (CD117), NRAS, RUNX1 (AML1)
Multiple Myeloma​
ATM, CCND1, IDH1, IDH2, KIT (CD117), LIG4, NRAS, TP53 (p53)
Myelodysplastic Syndromes​
CEBPA, DNMT3A, GATA2, GNB1, IDH1, IDH2, KIT (CD117), MPL, MSH6, NF1, NRAS, RUNX1 (AML1), SMAD9, TERC, TERT, TP53 (p53)
Myelofibrosis​
DNMT3A, IDH1, IDH2, MPL, NF1, NRAS, TP53 (p53)
Myeloproliferative Neoplasms​
DNMT3A, IDH1, IDH2, MPL, RUNX1 (AML1), SH2B3, TP53 (p53)
Polycythemia Vera​
DNMT3A, IDH1, NRAS, TP53 (p53)
Thrombocythemia​
IDH2, MPL, SH2B3, THPO, TP53 (p53)
Other Hematological Malignancies Genes​
BLM, EPCAM, HRAS, MLH1, MSH2, NBN, PMS2
Hereditary Breast & Ovarian Cancers (HBOC)
Familial Breast-Ovarian Cancer Susceptibility​
BRCA1, BRCA2, FGFR2, MAP3K1 (MEKK1), RAD51C, RAD51D, TOX3
Breast Cancer Carcinomas​
ATM, BARD1, BRCA1, BRCA2, BRIP1, CHEK2 (RAD53), ERBB2 (HER-2, NEU), ESR1 (ERα), MLH1, MSH2, MSH6, PALB2, PIK3CA (p110-alpha), PMS2, RAD51C, RAD51D
Breast Cancer Ductal Carcinomas​
CDH1 (E-Cadherin), FGFR2, MRE11, NBN, STK11 (LKB1), TP53 (p53)
Breast Cancer Susceptibility​
BARD1, BRCA2, PALB2, RECQL, XRCC3
Metastatic Breast Cancers​
BRCA1, BRCA2, ERBB2 (HER-2, NEU), ESR1 (ERα), NF1, PALB2, PIK3CA (p110-alpha), PTEN
Other Breast Cancer Genes​
APC, AXIN2, SDHB, SMARCA4, TSHR
Ovarian Cancer Epithelial Carcinomas​
ABRAXAS1, ATM, BARD1, BRCA1, BRCA2, BRIP1, CHEK2 (RAD53), ERBB2 (HER-2, NEU), MRE11, NBN, NF1, PALB2, PIK3CA (p110-alpha), PTEN, RAD51C, RAD51D, TP53 (p53)
Ovarian Cancer Mixed Adenosquamous Carcinomas​
BLM, CDH1 (E-Cadherin), DICER1, FANCC, FANCM, FGFR2, RAD50, RAD51, SMARCA4, STK11 (LKB1)
Other Ovarian Cancer Genes​
MLH1, RECQL, RINT1, XRCC2
Uterine Serous Carcinomas​
BLM, CDH1 (E-Cadherin), DICER1, FANCC, FANCM, FGFR2, RAD50, RAD51, SMARCA4
Lynch Syndrome​
EPCAM, MLH1, MSH2, MSH6, PMS2
Other Hereditary Breast & Ovarian Cancer Genes​
HMMR, MUTYH, NQO2, PGR, PHB, POLD1, PRKAR1A
Kidney Cancers
Hamartomas​
CDC73, DIS3L2
Lynch Syndrome​
EPCAM, MLH1, MSH6, PMS2
Nephroblastomas​
CDKN1C (p57Kip2), DIS3L2, TRIM28
Papillary Renal Cell Carcinomas​
FH, MET
Renal Cell Carcinomas​
BAP1, BRAF, FGFR3, FH, FLCN, HNF1A, HNF1B, MET, MITF, MSH2, MTOR, NRAS, PIK3CA (p110-alpha), PTEN, SDHA, SDHB, SDHC, SDHD, TMEM127, TP53 (p53), VHL
Rhabdoid Tumors​
SMARCA4, SMARCB1
Tuberous Sclerosis Complex​
TSC1, TSC2
Wilms Tumors​
BRAF, BRCA2, CDC73, CDKN1C (p57Kip2), DICER1, DIS3L2, FZD6, GPC3, PAX6, REST, VHL, WT1
Other Kidney Cancer Genes​
BUB1B
Myeloid Neoplasms
Acute Lymphoblastic Leukemia (ALL)​
BRAF, CDKN2A (P16INK4A), CDKN2B (p15INK4b), CREBBP (CBP), EP300, ETV6, EZH2, FBXW7, FLT3, GATA3, H2AC7, H2BC6, H2BC7, H3C4, H4C4, IKZF1, IKZF2, IKZF3, IL7R, JAK1, JAK2, JAK3, KRAS, MAPK1 (ERK2), NF1, NOTCH1, NRAS, PAG1, PAX5, PTEN, PTPN11, RB1, RUNX1 (AML1), SH2B3, TP53 (p53)
Acute Megakaryoblastic Leukemia (AMKL)​
ERG, GATA1, JAK2, MET, MPL, OLIG2, RUNX1 (AML1), SMO, TMPRSS2
Acute Myeloid Leukemia (AML)​
BRCA2, CEBPA, CHIC2, DDX41, DNMT3A, ETV6, FLT3, GATA1, GATA2, IDH1, IDH2, IKZF1, IKZF2, IKZF3, JAK2, KIT (CD117), KRAS, LPP, MLLT10, NRAS, PTPN11, RB1, RUNX1 (AML1), SH3GL1, TERT, TP53 (p53), WT1
Acute Promyelocytic Leukemia (APML; APL)​
CEBPA, RUNX1 (AML1)
Atypical Chronic Myeloid Leukemia (aCML)​
CBL, CEBPA, EZH2, FLT3, JAK2, KRAS, NRAS, RUNX1 (AML1), SETBP1
B Cell Acute Lymphoblastic Leukemia (B-ALL)​
IKZF1, JAK1, JAK2, PAX5
Chronic Lymphocytic Leukemia (CLL)​
BRAF, GNB1, NOTCH1, NRAS, PTPN11, TP53 (p53)
Chronic Myeloid Leukemia (CML)​
BRAF, CBL, CREBBP (CBP), DNMT3A, EZH2, IDH1, IDH2, IKZF1, JAK2, KRAS, NRAS, RUNX1 (AML1), TP53 (p53), WT1
Chronic Myelomonocytic Leukemia (CMML)​
CBL, CEBPA, DNMT3A, EZH2, FLT3, IDH1, IDH2, JAK2, KIT (CD117), KRAS, MPL, NF1, NRAS, PHF6, PTPN11, RUNX1 (AML1), SETBP1, TP53 (p53)
Early T-Cell Precursor Acute Lymphoblastic Leukemia​
BCL11B, BRAF, CDKN2A (P16INK4A), CDKN2B (p15INK4b), CTCF, DCLRE1C, DNM2, ECT2L, EED, EP300, ETV6, EZH2, FBXW7, FLT3, GATA2, GATA3, H1-5, HNRNPA1, HNRNPR, IKZF1, IL7R, JAK1, JAK3, KRAS, LEF1, LMO2, MYB, NF1, NOTCH1, NRAS, PHF6, PTEN, PTPN11, RB1, RELN, RUNX1 (AML1), SETD2, SH2B3, SUZ12, TAL1, WT1
Hairy Cell Leukemia​
BRAF, TP53 (p53)
Juvenile Myelomonocytic Leukemia​
CBL, KRAS, NF1, NRAS, PTPN11
T Cell Acute Lymphoblastic Leukemia (T-ALL)​
FBXW7, NOTCH1
Other Leukemia Genes​
APC, ATM, CDH1 (E-Cadherin), DICER1, DNAJC21, ERBB3, ERCC2 (XPD), ERCC4, KCNQ1, MSH2, MSH6, MUTYH, NBN, NSD1, RECQL4, RET, SOS1, STK11 (LKB1), TSC2
Acute Lymphoblastic Lymphomas​
CDKN2A (P16INK4A), CDKN2B (p15INK4b), NOTCH1, TP53 (p53)
B Cell Lymphomas​
BRAF, CHEK2 (RAD53), EZH2, TP53 (p53)
Follicular Lymphomas​
CREBBP (CBP), EP300, EZH2
Non-Hodgkin Lymphomas​
BRAF, NRAS, PIK3CA (p110-alpha), TP53 (p53)
T Cell Lymphomas​
ATM, DNMT3A, HAVCR2, IDH1, IDH2, JAK1, JAK3, SETD2
Other Lymphoma Genes​
B2M, BRCA2, CEBPA, KIT (CD117), KLHDC8B, MSH2, MSH6, MUTYH, PRF1, PTPN11, RB1, RECQL4, RET, STK11 (LKB1), TSC2
Myelodysplastic Syndromes​
CBL, CEBPA, DDX41, DNMT3A, ETV6, EZH2, FLT3, GATA2, GNB1, IDH1, IDH2, JAK2, JAK3, KIT (CD117), KRAS, MPL, NF1, NRAS, PHF6, PTPN11, RUNX1 (AML1), SETBP1, TERC, TERT, TP53 (p53), WT1
Myeloproliferative Neoplasms​
CBL, DNMT3A, EZH2, IDH1, IDH2, JAK2, MPL, RUNX1 (AML1), SH2B3, TP53 (p53)
Essential Thrombocythemia​
CBL, IDH2, JAK2, MPL, TP53 (p53)
Fanconi Anemia​
FANCA, FANCB, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCM, SLX4
Mastocytosis​
CBL, EZH2, IDH2, JAK2, KIT (CD117), KRAS, NRAS, RUNX1 (AML1)
Multiple Myeloma​
ATM, BRAF, BRCA2, CHEK2 (RAD53), FANCL, IDH1, IDH2, KIT (CD117), KRAS, MET, NRAS, RET, TP53 (p53)
Polycythemia Vera​
DNMT3A, EZH2, IDH1, JAK2, NRAS, TP53 (p53)
Primary Myelofibrosis​
CBL, DNMT3A, EZH2, IDH1, IDH2, JAK2, MPL, NF1, NRAS, SETBP1, TP53 (p53)
Systemic Mastocytosis​
CBL, DNMT3A, ETV6, EZH2, IDH2, JAK2, KIT (CD117), KRAS, NRAS, RUNX1 (AML1), SETBP1
Pancreatic Cancers
Adenocarcinomas​
ATM, BRCA1, BRCA2, CDKN2A (P16INK4A), CFTR, EPCAM, FANCC, MLH1, MSH2, MSH6, PALB2, PALLD, PMS2, PRSS1, SMAD4 (MADH4), SPINK1, STK11 (LKB1), TP53 (p53)
Adenomas​
TSC1, TSC2
Familial Pancreatic Cancers​
ATM, BRCA2, CDKN2A (P16INK4A), PALB2
Hereditary Pancreatitis​
CFTR, CTRC, PRSS1, PRSS2, SPINK1
Lynch Syndrome​
EPCAM, MLH1, MSH2, MSH6, PMS2
Multiple Endocrine Neoplasia​
CDKN1B (P27KIP1), MEN1
Pancreatic Cancer Susceptibility​
BRCA1, BRCA2, PALB2, PALLD, RABL3
Other Pancreatic Cancer Genes​
APC, BMPR1A (ALK3), CASR, CDK4, CPA1, NF1, VHL
Pediatric Cancers
Craniopharyngiomas​
APC, SMARCA4, SUFU, TSC1
Embryonal Rhabdomyosarcomas​
CARD11, CTNNB1, FGFR4, HRAS, KRAS, MDM2, MDM4, NF1, NRAS, PIK3CA (p110-alpha), RARA, TP53 (p53)
Ependymomas​
MEN1, NF2
Ewing's Sarcoma​
NF1, RET
Germ Cell Tumors​
BRAF, CBL, FANCM, PTEN
Hepatoblastomas​
CDK4, MSH6, TP53 (p53)
Hepatocellular Carcinomas​
APC, CREBBP (CBP), CTNNB1, IDH1, KRAS, MET, NRAS, PIK3CA (p110-alpha), TERT, TP53 (p53)
Lynch Syndrome​
EPCAM, MLH1, PMS2
Nephroblastomas​
BRCA2, CDKN1C (p57Kip2), DIS3L2, PAX6, POU6F2, REST, SMARCB1, WT1
Neuroblastomas​
ALK, PHOX2B, PTCH1
Osteosarcomas​
ATRX, CDKN2A (P16INK4A), CHEK2 (RAD53), RB1, RECQL4, TP53 (p53), TSC2
Retinoblastomas​
APC, CEBPA, MAX, RB1, STK11 (LKB1), TSC2
Rhabdomyosarcomas​
BRCA1, DICER1, FOXO1, MSH2, PAX3, PAX7
Other Pediatric Cancer Genes​
CDC73, PRKAR1A, VHL
Prostate Cancers
Adenocarcinomas​
AR, BRIP1, CHEK2 (RAD53), NBN, PTEN, RAD51C, RAD51D, TP53 (p53)
Advanced Prostate Cancers​
ATM, BRCA1, BRCA2, PALB2, PTEN
Lynch Syndrome​
EPCAM, MLH1, MSH2, MSH6, PMS2
Other Prostate Cancer Genes​
CDH1 (E-Cadherin), EHBP1, ELAC2, HOXB13, MSMB, RNASEL
Skin Cancers
Cutaneous Melanomas​
BAP1, CDK4, CDKN2A (P16INK4A), MC1R, MITF, POT1, XRCC3
Malignant Melanoma Susceptibility​
CDK4, CDKN2A (P16INK4A), MC1R, MITF, POT1, TERT, XRCC3
Malignant Melanomas​
CDK4, CDKN2A (P16INK4A), MC1R, MITF, POT1, XRCC3
Melanomas​
BRAF, BRCA1, BRCA2, CDK4, CDKN2A (P16INK4A), CDKN2B-AS1, CREBBP (CBP), IDH1, KIT (CD117), KRAS, MAP2K1, MAP2K2 (MEK2), MC1R, MITF, NRAS, PIK3CA (p110-alpha), POT1, PTEN, RAF1, RB1, TERT, TP53 (p53), TYR
Uveal Melanomas​
BAP1, BRCA2, CDKN2A (P16INK4A), CDKN2B (p15INK4b)
Xeroderma Pigmentosum​
DDB2, ERCC2 (XPD), ERCC3 (XPB), ERCC4, ERCC5, POLH, XPA, XPC
Other Skin Cancer Genes​
ATR, CYLD, FH, FLCN, PRKAR1A, PTCH2

Resources

Application Notes (1)
Kit Handbooks (2)
For ultrasensitive targeted next-generation sequencing of DNA for Ion Torrent NGS systems
For ultrasensitive targeted next-generation sequencing (NGS) of DNA for Illumina NGS systems
Safety Data Sheets (1)
Certificates of Analysis (1)
Template Files (1)
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