Target List
Drug Transporters
Metallothioneins
Mt2, Mt3
P-Glycoprotein Family Members
Abcb1a (Mdr1), Abcb1b, Abcb4, Abcc1 (Mrp1), Gpi1
Phase I Metabolizing Enzymes
Cyp11b2, Cyp17a1, Cyp19a1, Cyp1a1, Cyp1a2, Cyp27b1, Cyp2c29, Cyp2e1, Cyp3a11, Cyp3a44, Cyp4b1
Phase II Metabolizing Enzymes
Carboxylesterases
Ces1g, Ces2c
Decarboxylases
Gad1, Gad2
Dehydrogenases
Adh1, Adh4, Adh5, Alad, Aldh1a1 (Raldh1), Hsd17b1, Hsd17b2, Hsd17b3
Glutathione Peroxidases (GPx)
Gpx1, Gpx2, Gpx3, Gpx5, Gsta1, Gsta3, Gsta4, Gstm1 (Mgst1), Gstm2, Gstm3, Gstm4, Gstm5, Gstp1, Gstt1, Gstz1, Lpo, Mpo
Hydrolases
Asna1, Ephx1, Ephx2, Faah, Fbp1
Kinases
Hk2, Pklr, Pkm
Lipoxygenases
Alox12, Alox15, Alox5, Apoe
Oxidoreductases
Aoc1, Blvra, Blvrb, Cyb5r3, Gpx1, Gpx2, Gsr, Mthfr, Nos3 (eNOS), Nqo1, Srd5a1, Srd5a2
Paraoxonases
Pon1, Pon2, Pon3
Glutathione S-Transferases
Chst1, Gsta3, Gstm2, Gstm3, Gstm5, Gstp1, Gstt1, Mgst1, Mgst2, Mgst3
Other Phase II Metabolizing Enzymes
Nat1, Nat2, Comt, Ggt1
Other Drug Metabolism Genes
Ahr, Arnt, Gckr, Snn