Target List
G1 Phase & G1/S Transition
Cdk6, Cdkn3, Gpr132, Itgb1, Myb, Skp2, Slfn1
S Phase & DNA Replication
Cdc6, Cdc7, Mcm2, Mcm3, Mcm4, Mki67, Mre11a, Msh2, Rad17, Rad51
G2 Phase & G2/M Transition
Birc5, Cdkn3, Chek1, Ppm1d (Wip1)
M Phase
Aurkb, Brca2, Ccna1, Ccnb1, Cdc20, Cdc25a, Cdc25c, Cdc6, Cdk1 (Cdc2), Cdk2, Nek2, Rad21, Ran, Shc1, Smc1a, Stag1, Stmn1, Terf1, Wee1
Cell Cycle Checkpoint & Cell Cycle Arrest
Atr, Brca2, Casp3, Cdc25c, Cdk1 (Cdc2), Cdk5rap1, Cdkn1a (p21Cip1, Waf1), Cdkn1b (p27Kip1), Cdkn2a (p16INK4a), Cdkn2b (p15INK4b), Cdkn3, Chek1, Chek2 (Rad53), Cks1b, Ddit3 (Gadd153, Chop), Dst, Gadd45a, Hus1, Mad2l1, Mdm2, Msh2, Nbn (Nbs1), Notch2, Pkd1, Pmp22, Ppm1d (Wip1), Rad9a, Rb1, Sfn (14-3-3σ), Slfn1, Smc1a, Tsg101
Regulation of the Cell Cycle
Abl1, Atr, Aurka, Bcl2, Brca2, Ccna1, Ccna2, Ccnb1, Ccnb2, Ccnc, Ccnd1, Ccnd2, Ccnd3, Ccne1, Ccnf, Cdc20, Cdc25c, Cdc6, Cdk1 (Cdc2), Cdk4, Cdk6, Cdkn1a (p21Cip1, Waf1), Cks1b, E2f1, E2f2, E2f3, E2f4, Gadd45a, Itgb1, Rad9a, Ran, Rb1, Sfn (14-3-3σ), Shc1, Skp2, Tfdp1
Negative Regulation of the Cell Cycle
Atm, Brca1, Casp3, Cdkn2a (p16INK4a), Cdkn2b (p15INK4b), Rbl1, Rbl2, Trp53 (p53), Trp63 (Tp73l)