Target List
JAK & STAT Proteins
Janus Kinases
Jak1, Jak2, Jak3, Tyk2
STAT Family Members
Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, Stat6
JAK / STAT Signaling Regulators
Pias1, Pias2, Prl, Ptpn1 (Ptp1b), Ptprc (Cd45), Sh2b2, Socs1, Socs2, Socs3, Socs4, Socs5
Receptors Binding & Activating JAK Proteins
Sh2b2
Cell Surface Receptors
Csf1r, Cxcl9 (Mig), Egfr, Epor, Fas, Fcgr1, Ghr, Ifnar1, Ifngr1, Il10ra, Il10rb, Il2ra (Cd25), Il2rg, Il4ra (Cd124), Il6st (Gp130), Insr, Mpl (Tpor), Nr3c1 (GR), Pdgfra, Prlr, Ptprc (Cd45)
STAT-Interacting Proteins
Crk, Sh2b1, Src, Stam, Stub1
STAT-Interacting Transcription Factors & Regulators
Transcriptional Regulation
Ifng, Irf1, Jun, Nfkb1, Smad2, Smad3, Smad4
Other Transcription Factors & Regulators
Cebpb, Gata3, Junb, Myc, Nr3c1 (GR), Smad1, Smad5, Sp1, Spi1 (Sfpi1, PU1), Usf1, Yy1
STAT-Induced
STAT1-Induced
Cxcl9 (Mig), Irf1, Nos2 (iNos)
STAT3-Induced
A2m, Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Ccnd1, Cdkn1a (p21Cip1, Waf1), Cebpd, Crp, Fas, Irf1, Junb, Lrg1, Mcl1, Myc, Socs1, Socs3
STAT4-Induced
Fcgr1, Ifng, Irf1, Myc
STAT5-Induced
Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Ccnd1, Cdkn1a (p21Cip1, Waf1), Il2ra (Cd25), Irf1, Osm
STAT6-Induced
Fcer2a, Gata3, Il4, Il4ra (Cd124)
STAT1 / STAT2 / p48 Induced
Isg15, Oas1a
Apoptosis
Akt1, Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Cdkn1a (p21Cip1, Waf1), Cebpb, Fas, Ifng, Il4, Jak2, Myc, Nfkb1, Prlr
Cell Growth and / or Maintenance
Cell Cycle
Ccnd1, Cdkn1a (p21Cip1, Waf1), Jun, Junb
Cell Proliferation
Il2ra (Cd25), Jak2, Myc, Ptprc (Cd45), Stat4, Stat6
Cell Growth
Egfr, Ifng, Il4, Osm, Pdgfra, Socs1, Socs2, Socs3, Socs4, Socs5
Cell Differentiation
Ccnd1, Cebpb, Gata3, Il20, Il4, Jak2, Jun, Nos2 (iNos), Prlr, Ptprc (Cd45), Smad2, Socs2, Socs5, Spi1 (Sfpi1, PU1), Stat3, Stat5a, Stat5b
Immune Response
Acute-Phase Response
Crp, F2 (Thrombin), Stat3
Inflammatory Response
Cebpb, Cxcl9 (Mig), Ifng, Il20, Il2ra (Cd25), Irf1, Nfkb1, Nos2 (iNos)
Lymphocyte Activation
Ifng, Il4, Prlr
Other Immune Response Genes
Crk, Fas, Fcgr1, Gbp2b, Il4ra (Cd124), Il6st (Gp130), Irf9, Isg15, Oas1a, Osm, Ptpn11, Sh2b1, Src, Stam, Stub1