Target List
Parkin Complex
Hspa4 (Hsp70), Park7, Stub1
Parkin Substrate
Atxn2, Atxn3, Gpr37, Syt11
Cell Adhesion Molecules
Apc, App, Cdh8, Fn1, Nfasc, Nrxn3, Pten, Tpbg
Ubiquitination
Cdc27, Cul2, Fbxo9, Lrrk2, Prkn, Pink1, Skp1a, Stub1, Uba1, Ubc, Ube2i, Ube2k, Ube2l3, Uchl1, Usp34, Pan2
Inflammation
Fn1, Prdx2, Ywhaz
Apoptosis
Pro-Apoptotic
Apc, App, Casp1 (Ice), Casp3, Casp8 (Flice), Casp9, Cul2, Mapk9 (Jnk2), Psen2, Pten
Anti-Apoptotic
Apc, Bdnf, Casp3, Casp9, Nefl, Nr4a2 (Nurr1), Opa1, Ppid, Prdx2, Psen2, Pten, Slc25a4, Snca, Tcf7l2, Ubc, Ywhaz
Mitochondrial Genes
Casp3, Casp7, Casp8 (Flice), Hspa4 (Hsp70), Lrrk2, Nefl, Opa1, Park7, Pink1, Pten, Slc25a4, Snca, Th, Uchl1, Vamp1, Vdac3, Ywhaz
Synaptic Vesicles
Lrrk2, Sept5, Sv2b, Syngr3, Syt1, Syt11, Th
Signal Transduction
Dopaminergic Signaling
Ddc, Drd2, Htr2a, Nr4a2 (Nurr1), Nsg1, Prkn, Park7, Pink1, Sept5, Slc6a3 (Dat), Snca, Th
GABAergic Signaling
Drd2, Gabbr2
MAP Kinase Signaling
Apc, Fgf13, Mapk9 (Jnk2), Prdx2, Rgs4
Notch Signaling
App, Psen2, Spen
Cytoskeleton Regulators
Apc, Cdc42, Mapt, Nefl, Prkn
Ion Transport
Atp2b2, Cadps, Cxxc1, Drd2, Egln1, Gbe1, Gria3, Htr2a, Kcnj6, Nsf, Psen2, S100b, Srsf7, Slit1, Snca, Vdac3
Channels & Transporters
Atp2b2, Gria3, Slc18a2 (Vmat2), Slc6a3 (Dat), Slc25a4, Sv2b, Syt1, Syt11, Vdac3
Other Parkinson's Disease Genes
Aldh1a1 (Raldh1), Basp1, Chgb, Dlk1, Ncoa1, Ntrk2, Rtn1