Target List
Drug Transporters
Metallothioneins
Mt3
P-Glycoprotein Family Members
Abcb1a (Mdr1), Abcc1 (Mrp1), Abcc2 (Cmoat, Mrp2), Abcc3 (Mlp2, Mrp3), Gpi
Phase I Metabolizing Enzymes
Cytochrome P450s
Cyp17a1, Cyp19a1, Cyp1a1, Cyp1a2, Cyp1b1, Cyp27b1, Cyp2b15, Cyp2b3, Cyp2c13, Cyp2c6v1, Cyp2c7, Cyp2e1, Cyp3a18, Cyp4b1
Phase II Metabolizing Enzymes
Carboxylesterases
Ces1a, Ces2c (QuantiNova Symbol: LOC100365112)
Decarboxylases
Gad1, Gad2
Dehydrogenases
Adh1, Adh4, Alad, Aldh1a1, Hsd17b1, Hsd17b2, Hsd17b3
Glutathione Peroxidases (GPx)
Gpx1, Gpx2, Gpx3, Gpx4, Gpx5, Gsta1, Gsta4, Gstm1 (Mgst1), Gstm2, Gstm3, Gstm4, Gstm5 (QuantiNova Symbol: Gstm3l), Gstp1, Gstt1, Lpo, Mpo
Hydrolases
Ephx1, Faah, Fbp1
Kinases
Hk2, Pklr, Pkm
Lipoxygenases
Alox15, Alox5, Apoe
Oxidoreductases
Blvra, Blvrb, Cyb5r3, Gpx1, Gpx2, Gsr, Mthfr, Nos2 (Nos2a, iNos), Nos3 (eNOS), Nqo1, Srd5a1, Xdh (Srd5a2)
Paraoxonases
Pon1, Pon2, Pon3
Glutathione S-Transferases
Chst1, Gsta1, Gstm2, Gstm3, Gstm5 (QuantiNova Symbol: Gstm3l), Gstp1, Gstt1, Mgst1, Mgst2, Mgst3
Transferases
Nat1
Other Phase II Metabolizing Enzymes
Comt, Ggt1
Other Drug Metabolism Genes
Ahr, Aoc1, Arnt, Asna1, Gckr, Marcks, Smarcal1, Snn