Target List
Apoptosis
Akt1, Bcl2, Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Casp8 (Flice), Casp9, Faslg
Necrosis
Cyld, Grb2, Mag, Parp2, Pvr, Txnl4b
DNA Damage & Repair
Atm, Brca1, Cdkn1a (Cip1, Waf1), Ercc2 (Xpd), Mdm2, Rad51
Mitochondrial Energy Metabolism
Arrdc3, Asb1, Cyb561d1, Dnajb1, Hspa1a (Hsp70-1), Slc25a25
Fatty Acid Metabolism (β-Oxidation)
Acadm, Acadvl, Acox1, Cpt1a, Cpt1b, Cpt2
Oxidative Stress & Antioxidant Response
Akr1c2, Fhl2, Gclm, Hmox1, Ncoa7, Nqo1, Slc7a11
Heat Shock Response
Hsf1 (Tcf5), Hsp90b1, Hspa4 (Hsp70), Hspa5 (Grp78), Hspb1 (Hsp27), Hspd1
Endoplasmic Reticulum Stress & Unfolded Protein Response
Adm2, Asns, Dnajb9, Herpud1, Inhbe, Trib3 (Skip3), Uhrf1
Cytochrome P450s & Phase I Drug Metabolism
Cyp1a1, Cyp1a2, Cyp2d4, Cyp2e1, Cyp3a18
Steatosis
Cd36 (QuantiNova Symbol: RGD1565355), Edn1, Fasn, Lpl, Ppara, Scd, Srebf1
Cholestasis
Abcb1a (Mdr1), Abcc2 (Cmoat, Mrp2), Abcc3 (Mlp2, Mrp3), Atp8b1, Edn1, Pdyn, Rdx, Slc51a
Phospholipidosis
Asah1, Hpn, LOC100909595 (Slc2a3), LOC299282 (QuantiNova Symbol: Serpina3n), Lss, Tagln, Wipi1
Immunotoxicity
Adh1, F2 (Thrombin), Hpx, Lyz2, Metap2, Mki67, Nr5a2, Trim10