Target List
NFκB Signaling
NFκB Signaling Ligands & Receptors
CARD10, CD40 (TNFRSF5), EGFR, F2R, FASLG (TNFSF6), IL10, IL1B, IL1R1, CXCL8, NOD1 (CARD4), TLR1A, TLR2A, TLR3, TLR4, TNFRSF1A, TNFRSF1B, TNFRSF10B, TNFSF10 (TRAIL)
Signaling Downstream of NFκB
BIRC2 (c-IAP-2), FADD, IRAK2, IRF1, MYD88, RIPK1, RIPK2, TBK1, TICAM1 (TRIF), TNFAIP3, TOLLIP, TRADD, TRAF2, TRAF3, TRAF5, TRAF6
Cytoplasmic Sequestering / Releasing of NFκB
CHUK (IKKα), IKBKB, IKBKE, NFKBIA (IκBα, MAD3), NFKBIB, NFKBIE
Transcription Factors
ATF2, CREBBP, NFKB1, NFKB2, REL, RELA, RELB, SMAD3
NFκB Responsive Genes
Immune Response
CCL20 (MIP-3A), CCL5 (RANTES), CD83, CSF1 (MCSF), CSF2 (GM-CSF), CSF3 (GCSF), CXCL8, IFNA3, IFNG
Apoptosis
AGT, BCL2A1, BCL2L1 (BCLXL), LITAF (TNF), PCASP1
Other Factors Involved in NFκB Pathway
Kinases
AKT1, EIF2AK2, MAPK1 (ERK2), MAP3K1, RAF1, ZAP70
Transcription Factors
ATF1, EGR1, FOS, JUN, STAT1
Other NFκB Signaling Genes
BCL10, CARD11, CASP1 (ICE), CASP8 (FLICE), CFLAR, HMOX1, LITAF (TNF), PSIP1, RHOA, SLC20A1, STX11, TIFA, TNFAIP2