Target List
Toll-Like Receptors
cd180, sigirr, tlr1, tlr2, tlr3, tlr4al (TLR4), tlr4ba (TLR4), tlr4bb, tlr5a, tlr5b (TLR5), tlr7, tlr8a, tlr8b, tlr9
Pathogen-Specific Responses
Bacterial Response
cd180, cxcl8a, fosab, hmgb1a, hrasb, hsp70.3, il10, il10ra, il12a, il12ba, il1b, il6, irak1, jun, lta, ly86, nfkbiaa, ptgs2a, rela, ripk1l (RIPK1), ripk2, tlr2, tlr4al (TLR4), tlr4ba (TLR4), tlr4bb, tnfb, tnfrsf1a
Viral Response
eif2ak2, ifng1, ifnphi3, il12a, il12ba, il6, irf3, irf7, prkra, rela, tbk1, tlr3, tlr7, tlr8a, tlr8b, tnfa
Fungal / Parasitic Response
cxcl8a, hrasb, hsp70.3, tirap, tlr2
Toll-Like Receptor (TLR) Signaling
Negative Regulation of Toll-Like Receptor (TLR) Signaling
sarm1, sigirr, tollip
TICAM1 (TRIF)-Dependent (MYD88-Independent) Signaling
irf3, irf7, map3k7, nr2c2, peli1a, tab1, tab2, tbk1, tlr3, tlr4al (TLR4), tlr4ba (TLR4), tlr4bb, traf3, traf6
MYD88-Dependent Signaling
irak1, map3k7, myd88, nr2c2, tab1, tab2, tirap, tlr1, tlr2, tlr4al (TLR4), tlr4ba (TLR4), tlr4bb, tlr5a, tlr5b (TLR5), tlr7, tlr8a, tlr8b, tlr9, traf3, traf6
Signaling Downstream of Toll-Like Receptors
NFκB Signaling
btk, casp8, cd40, chuk, ecsit, fadd, ikbkb, il10, il10ra, il1b, irak1, irf3, irf7, map3k1, map3k7, map4k4, nfkb1, nfkb2, nfkbiaa, nfkbil1, nfrkb, pparaa, rel, rela, tnfa, tnfrsf1a, ube2na
JNK / p38 Signaling
elk1, fosab, il1b, jun, map2k4a (MAP2K4), map2k6, map3k1, map3k7, mapk8a (jnk1), mapk8a (MAPK8), mapk8ip3, tnfa
JAK / STAT Signaling
ifng1, il12a, il12ba, il6
Interferon Regulatory Factor (IRF) Signaling
ifng1, ifnphi1, ifnphi3, irf1a, irf3, irf7, tbk1
Cytokine Signaling
ccl39.6, csf3a, cxcl11.1, il1b, il6, irak1, rela, sigirr, tnfa, tnfrsf1a
Regulation of Adaptive Immunity
cd80/86, hspd1, ifng1, il10, il10ra, il12a, il12ba, il1b, map3k7, traf3, traf6
Toll-Like Receptor Interacting Proteins & Adaptors
btk, hmgb1a, hrasb, hsp70.3, hspd1, ly86, mapk8ip3, myd88, peli1a, ripk1l (RIPK1), ripk2, sarm1, tirap, tollip
Downstream Effectors of Toll-Like Receptor Signaling
casp8, ecsit, eif2ak2, fadd, irak1, irak4, map3k7, nr2c2, pparaa, prkra, tab1, tab2, traf3, traf6, ube2na