PPP2R5D Gene Summary

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
PPP2R5D
Official Name
protein phosphatase 2 regulatory subunit B'delta [Source:HGNC Symbol;Acc:HGNC:9312]
Ensembl ID
ENSG00000112640
Bio databases IDs NCBI: 5528 Ensembl: ENSG00000112640
Aliases protein phosphatase 2 regulatory subunit B'delta
Synonyms
B56D,B56delta,B'delta,B'δ,HJS1,LOC100909464,MRD35,PP2A B delta,PP2A B' delta,PP2A B δ,PP2A B' δ,protein phosphatase 2 regulatory subunit B'delta,protein phosphatase 2, regulatory subunit B', delta,protein phosphatase 2 regulatory subunit B'δ,protein phosphatase 2, regulatory subunit B', δ,TEG-271,Tex271
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein phosphatase
  • phosphatase
  • protein phosphatase regulator
  • Protein phosphatase 2A regulatory B subunit (B56 family)
  • phosphatase activator
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • epithelial cancer
  • epithelial neoplasia
  • abdominal cancer
  • cancer
  • digestive system cancer
  • liver cancer
  • liver neoplasia
  • autosomal dominant mental retardation type 35
  • neurodevelopmental disorder
  • heart failure
regulated by
regulates
role in cell
  • proliferation
  • phosphorylation in
  • expression in
  • damage in
  • development
  • damage
  • checkpoint recovery in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • cytosol
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the PPP2R5D gene, providing context for its role in the cell.

biological PROCESS

Functions and activities the gene product is involved in
  • signal transduction
  • negative regulation of peptidyl-threonine phosphorylation
  • protein dephosphorylation
  • nervous system development
  • positive regulation of protein dephosphorylation

cellular COMPONENT

Where in the cell the gene product is active
  • nucleus
  • cytosol
  • protein phosphatase type 2A complex
  • nucleoplasm

molecular FUNCTION

What the gene product does at the molecular level
  • phosphoprotein phosphatase activity
  • protein binding
  • protein phosphatase activator activity
  • protein phosphatase regulator activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.