IL1R2 Gene Summary
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]
Details
| Type | Protein Coding |
| Official Symbol | IL1R2 |
| Official Name | interleukin 1 receptor type 2 [Source:HGNC Symbol;Acc:HGNC:5994] |
| Ensembl ID | ENSG00000115590 |
| Bio databases IDs | |
| Aliases | interleukin 1 receptor type 2 |
| Synonyms | CD121b,CDW121B,IL-1 beta r,IL1bRb,IL1R2c,IL1RB,IL-1RT-2,IL-1R type II,IL-1 β r,interleukin 1 receptor type 2,interleukin 1 receptor, type II |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- CD19_double_Ig
- immunoglobulin domain
- stalk region
- Immunoglobulin like
- transmembrane domain
- Immunoglobulin I-set domain
- protein binding
- interleukin-1 receptor
- interleukin-1 binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the IL1R2 gene plays a role, providing insight into its function and relevance in health or disease.
- FAK Signaling
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- NF-κB Signaling
- Osteoarthritis Pathway
- p38 MAPK Signaling
- PPAR Signaling
- PPARα/RXRα Activation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- STAT3 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- endometriosis
- arthritis
- oral submucous fibrosis
- familial hemophagocytic lymphohistiocytosis
- insulin-dependent diabetes mellitus
- Sjogren syndrome keratoconjunctivitis sicca
- K/BxN serum transfer arthritis
- Parkinson disease
- colorectal cancer
role in cell
- cellular infiltration by
- expression in
- function
- response
- number
- abnormal number
- apoptosis
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- membrane surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IL1R2 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- immune response
- negative regulation of protein processing
- negative regulation of interleukin-1 alpha production
- cytokine-mediated signaling pathway
- negative regulation of cytokine production involved in inflammatory response
- protein processing
- negative regulation of interleukin-1-mediated signaling pathway
cellular COMPONENT
Where in the cell the gene product is active
- cytoplasm
- extracellular region
- plasma membrane
molecular FUNCTION
What the gene product does at the molecular level
- interleukin-1, Type II, blocking receptor activity
- protein binding
- interleukin-1 receptor activity
- interleukin-1 binding