APOC1 Gene Summary
This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | APOC1 |
| Official Name | apolipoprotein C1 [Source:HGNC Symbol;Acc:HGNC:607] |
| Ensembl ID | ENSG00000130208 |
| Bio databases IDs | |
| Aliases | apolipoprotein C1 |
| Synonyms | ALPCI,APOC1B,Apo-CI,Apo-CIB,apolipoprotein C1,APOLIPOPROTEIN C-I,LRRG04,NEWGENE 2134 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Apolipoprotein C-I (ApoC-1)
- phospholipid binding
- binding protein
- fatty acid binding
- enzyme inhibitor activity
- phospholipase inhibitor
- protein binding
- enzyme activator activity
- transporter
Pathways
Biological processes and signaling networks where the APOC1 gene plays a role, providing insight into its function and relevance in health or disease.
- Atherosclerosis Signaling
- Clathrin-mediated Endocytosis Signaling
- FXR/RXR Activation
- IL-12 Signaling and Production in Macrophages
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Maturity Onset Diabetes of Young (MODY) Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver disease
- cancer
- keloid
- psoriasis
- neoplasia
- metabolic syndrome X
- Alzheimer disease
- epithelial cancer
- metastasis
- COVID-19
role in cell
- expression in
- apoptosis
- phosphorylation in
- production in
- proliferation
- generation in
- migration
- invasion by
- size
- efflux in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Endoplasmic Reticulum
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the APOC1 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- negative regulation of fatty acid biosynthetic process
- chylomicron remnant clearance
- regulation of cholesterol transport
- high-density lipoprotein particle remodeling
- cholesterol metabolic process
- triglyceride metabolic process
- lipoprotein metabolic process
- negative regulation of lipid metabolic process
- negative regulation of very-low-density lipoprotein particle clearance
- negative regulation of lipoprotein lipase activity
- negative regulation of phosphatidylcholine catabolic process
- lipid metabolic process
- plasma lipoprotein particle remodeling
- very-low-density lipoprotein particle assembly
- negative regulation of cholesterol transport
- cholesterol efflux
- negative regulation of receptor-mediated endocytosis
- phospholipid efflux
- negative regulation of lipid catabolic process
- very-low-density lipoprotein particle clearance
cellular COMPONENT
Where in the cell the gene product is active
- very-low-density lipoprotein particle
- chylomicron
- high-density lipoprotein particle
- endoplasmic reticulum
- extracellular region
molecular FUNCTION
What the gene product does at the molecular level
- protein binding
- fatty acid binding
- phospholipase inhibitor activity
- phosphatidylcholine-sterol O-acyltransferase activator activity
- lipase inhibitor activity
- phosphatidylcholine binding