CDC25A Gene Summary
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CDC25A |
| Official Name | cell division cycle 25A [Source:HGNC Symbol;Acc:HGNC:1725] |
| Ensembl ID | ENSG00000164045 |
| Bio databases IDs | |
| Aliases | cell division cycle 25A, CDC25 homolog A (S. pombe), M-phase inducer phosphatase 1 |
| Synonyms | CDC25A2,cell division cycle 25A,D9Ertd393e |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein-tyrosine-phoshatase
- cyclin B1-CDK1 binding domain
- catalytic domain
- Rhodanese Homology Domain
- protein binding
- Rhodanese-like domain
- phosphatase domain
- RHOD
- KEN box
- M-phase inducer phosphatase
- protein phosphatase
- phosphatase
- chaperone binding
- MAP kinase site
Pathways
Biological processes and signaling networks where the CDC25A gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- atopic dermatitis
- organismal death
- polycythemia vera
- autosomal dominant polycystic liver disease
- essential thrombocythemia
- cervical cancer
- diabetic nephropathy
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- expression in
- activation in
- replication in
- phosphorylation in
- cell death
- damage in
- survival
- apoptosis
- binding in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear envelope
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CDC25A gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- cell proliferation
- cell division
- G2/M transition of mitotic cell cycle
- G1/S transition of mitotic cell cycle
- response to radiation
- cellular response to UV
- positive regulation of DNA replication
- positive regulation of G2/M transition of mitotic cell cycle
- regulation of cyclin-dependent protein kinase activity
cellular COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
molecular FUNCTION
What the gene product does at the molecular level
- phosphoprotein phosphatase activity
- protein kinase binding
- protein binding
- protein tyrosine phosphatase activity
- chaperone binding