Mmp14 Gene Summary [Mouse]
This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit craniofacial dysmorphism, arthritis, osteopenia, dwarfism, and fibrosis of soft tissues. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | Mmp14 |
| Official Name | matrix metallopeptidase 14 (membrane-inserted) [Source:MGI Symbol;Acc:MGI:101900] |
| Ensembl ID | ENSMUSG00000000957 |
| Bio databases IDs | |
| Aliases | matrix metallopeptidase 14 (membrane-inserted) |
| Synonyms | matrix metallopeptidase 14, matrix metallopeptidase 14 (membrane-inserted), MMP-X1, MT1-MMP, MT-MMP, MT-MMP-1, sabe, WNCHRS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mmp14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hemopexin-like repeats
- hemopexin C-terminal domain
- blades of the PEX domain
- hemopexin domain
- peptidase
- O-linked glycosylation site
- signal peptide
- Zinc-dependent metalloprotease
- Putative peptidoglycan binding domain
- zinc ion binding
- cytoplasmic domain
- furin cleavage consensus sequence
- aminopeptidase
- Src phosphorylation site
- fibronectin-like domain
- Matrixin
- metalloexopeptidase
- catalytic domain
- HX
- linker domain
- protein binding
- ZnMc
- endopeptidase
- serine endopeptidase
- integrin binding
- transmembrane domain
- hinge domain
- active site
- cytosolic tail domain
- pro domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Mmp14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Axonal Guidance Signaling
- Bladder Cancer Signaling
- Colorectal Cancer Metastasis Signaling
- Ephrin A Signaling
- Estrogen Receptor Signaling
- FAK Signaling
- Granulocyte Adhesion and Diapedesis
- HIF1α Signaling
- Inhibition of Matrix Metalloproteases
- Leukocyte Extravasation Signaling
- Molecular Mechanisms of Cancer
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- cutaneous melanoma
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- cancer
- fibrosis
- breast carcinoma
- breast cancer
- diabetes mellitus
phenotypes
- abnormal Meckel's cartilage morphology
- abnormal axial skeleton morphology
- abnormal basement membrane morphology
- abnormal bone mineralization
- abnormal bone ossification
- abnormal bone remodeling
- abnormal bronchiole morphology
- abnormal cartilage development
- abnormal cartilage morphology
- abnormal chondrocyte morphology
- abnormal club cell morphology
- abnormal cranial suture morphology
- abnormal cranial vertex morphology
- abnormal craniofacial morphology
- abnormal cranium morphology
- abnormal dendritic cell physiology
- abnormal fontanelle morphology
- abnormal forelimb morphology
- abnormal gait
- abnormal incisor morphology
- abnormal interparietal bone morphology
- abnormal joint morphology
- abnormal kidney corticomedullary boundary morphology
- abnormal kidney development
- abnormal kidney morphology
- abnormal kidney papilla morphology
- abnormal long bone epiphyseal plate morphology
- abnormal long bone epiphyseal plate proliferative zone
- abnormal long bone morphology
- abnormal lung morphology
- abnormal neurocranium morphology
- abnormal orbit morphology
- abnormal osteoclast physiology
- abnormal parietal bone morphology
- abnormal postnatal growth/weight/body size
- abnormal pulmonary alveolus morphology
- abnormal pulmonary elastic fiber morphology
- abnormal skeletal muscle fiber morphology
- abnormal skeleton development
- abnormal skeleton physiology
- abnormal submandibular gland branching morphogenesis
- abnormal terminal bronchiole morphology
- abnormal tooth development
- abnormal trabecular bone morphology
- abnormal upper incisor morphology
- absent alveolar pores
- absent sexual maturation
- arthritis
- cachexia
- centrally nucleated skeletal muscle fibers
- decreased angiogenesis
- decreased body size
- decreased body weight
- decreased bone mineral density
- decreased cranium height
- decreased cranium length
- decreased cranium width
- decreased kidney cell proliferation
- decreased length of long bones
- decreased renal glomerulus number
- decreased submandibular gland size
- delayed bone ossification
- delayed endochondral bone ossification
- delayed tooth eruption
- dilated pulmonary alveolar ducts
- dilated respiratory conducting tubes
- disproportionate dwarf
- domed cranium
- enlarged optic nerve
- exophthalmos
- focal hair loss
- hypoactivity
- impaired branching involved in ureteric bud morphogenesis
- impaired lung alveolus development
- impaired osteoblast differentiation
- increased or absent threshold for auditory brainstem response
- increased percent body fat/body weight
- increased skeletal muscle fiber size
- increased width of hypertrophic chondrocyte zone
- infertility
- kidney cortex hypoplasia
- kyphosis
- lethality at weaning complete penetrance
- loose skin
- lordosis
- macrophthalmia
- malocclusion
- no abnormal phenotype detected
- osteoporosis
- overexpanded pulmonary alveoli
- postnatal lethality
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- premature death
- prenatal lethality incomplete penetrance
- pulmonary hypoplasia
- round head
- short humerus
- short incisors
- short limbs
- short lower incisors
- short mandible
- short maxilla
- short snout
- short upper incisors
- skeletal muscle fibrosis
- skeletal muscle interstitial fibrosis
- skin fibrosis
- small cranial cavity
- small ears
- small kidney
- small lung
- small mandible
role in cell
- phosphorylation in
- activation in
- apoptosis
- expression in
- necrosis
- recruitment
- formation
- formation in
- degradation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma membrane fraction
- Golgi lumen
- F-actin structure
- intermediate filament cytoskeleton
- Cytoplasm
- invadopodia
- cell-matrix contacts
- cell surface
- cell periphery
- intracellular space
- apical compartment
- membrane surface
- cellular membrane
- focal adhesions
- podosomes
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- centrosome
- Golgi Apparatus
- cell-cell contacts
- granules
- cytosol
- membrane ruffles
- caveolae
- Golgi membrane
- perinuclear space
- early endosomes
- late endosomes
- cytoplasmic vesicles
- lateral cell-cell contacts
- brush border
- clathrin-coated pits
- cellular protrusions
- membrane processes
- filopodia
- cell membrane leading edge
- plasma
- lamellipodia
- macropinosomes
- centrosomal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mmp14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- head development
- response to estrogen stimulus
- male gonad development
- craniofacial suture morphogenesis
- branching morphogenesis of a tube
- negative regulation of Notch signaling pathway
- response to mechanical stimulus
- zymogen activation
- response to oxidative stress
- positive regulation of cell growth
- response to hypoxia
- skeletal system development
- angiogenesis
- positive regulation of myotube differentiation
- positive regulation of protein processing
- lung development
- astrocyte cell migration
- protein catabolic process
- extracellular matrix disassembly
- embryonic cranial skeleton morphogenesis
- response to organic cyclic compound
- positive regulation of B cell differentiation
- ovarian follicle development
- tissue remodeling
- negative regulation of focal adhesion assembly
- cell motility
- proteolysis
- extracellular matrix organization
- endothelial cell proliferation
- endodermal cell differentiation
- endochondral ossification
- chondrocyte proliferation
- protein processing
- collagen catabolic process
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- macropinosome
- Golgi lumen
- plasma membrane
- nucleus
- extracellular space
- intermediate filament cytoskeleton
- focal adhesion
- melanosome
- cytoplasm
- cytosol
- cytoplasmic vesicle
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- serine-type endopeptidase activity
- endopeptidase activity
- metalloaminopeptidase activity
- integrin binding
- metalloendopeptidase activity