Target List
Senescence Pathway
Atm, Bmi1 (Pcgf4), Ccnd1, Ccne1, Cdk2, Cdk4, Cdk6, Cdkn1a (Cip1, Waf1), Cdkn2a (INK4A, p16, p19ARF), Chek2, E2f1, E2f3, Ets1, Ets2, Mdm2, Nuak1, Rb1, Rbl2, Tp53 (p53), Twist1
Senescence Initiators
p53 / pRb Signaling & the Cell Cycle
Akt1, Aldh1a3, Ccna2, Ccnb1, Cdc25c, Cdkn1c (p57KIP2), Cdkn2b (p15), Cdkn2c (p18), Cited2, Creg1, Gsk3b, Id1, Igf1r, Igfbp3, Ing1, LOC100909750 (Abl1), Map2k6 (Mek6, Mkk6), Mapk14 (p38alpha), Morc3, Myc, Pcna, Pik3ca (p110-alpha), Plau (UPAM), Rbl1, Serpinb2 (Pai-2), Serpine1 (Pai-1), Sirt1 (QuantiNova Symbol: AABR07044925.1), Sparc, Tgfb1
Interferon Signaling
Aldh1a3, Cdkn1a (Cip1, Waf1), Cdkn1b (P27KIP1), Egr1, Ifng, Igfbp3, Igfbp7, Irf3, Irf5, Irf7, Nfkb1, Rb1, Serpinb2 (Pai-2)
Insulin Growth Factor (IGF) Related
Igf1, Igf1r, Igfbp3, Igfbp5, Igfbp7
MAP Kinase Signaling
Hras, Map2k1 (MEK1), Map2k3 (Mek3), Map2k6 (Mek6, Mkk6), Mapk14 (p38alpha)
Oxidative Stress
Aldh1a3, Hras, Mapk14 (p38alpha), Nox4, Prkcd, Sod1, Sod2
DNA Damage & Repair
Atm, Gadd45a, Nbn (Nbs1), Pcna, Terf2, Tert, Tp53bp1
Senescence Responses
p53 Effectors
Aldh1a3, E2f1, Hras, Igfbp3, Myc
p21 Effectors
Calr
p16 Effectors
Tbx2, Tbx3
Cytoskeleton Regulators
Akt1, Fn1, Hras, Pik3ca (p110-alpha), Plau (UPAM), Serpine1 (Pai-1), Sparc, Thbs1 (TSP-1, Tsp1), Vim
Cell Adhesion Molecules
Cd44, Col1a1, Col3a1, Tgfb1, Tgfb1i1, Thbs1 (TSP-1, Tsp1)
Other Senescence Response Genes
Glb1, Pten, Stt3a