Target List
p53 Activation
Atm, Atr, Bbc3, Brca1, Cdkn1a (p21Cip1, Waf1), Cdkn2a (p16INK4a), Chek1, Chek2 (Rad53), Ep300, Foxo3, Mdm2, Msh2, Pmaip1 (NoxA), Sirt1, Trp63 (Tp73l), Trp73
p53 Regulators & Interactors
Cdkn2a (p16INK4a), Dnmt1, Mdm2, Mdm4, Sirt1, Trp53bp2, Trp63 (Tp73l), Trp73
p53 Targets
Apoptosis
Apaf1, Bax, Bbc3, Btg2, Casp9, Egfr, Esr1 (Erα), Fas, Pmaip1 (NoxA), Prkca, Sfn (14-3-3σ), Tnf, Tnfrsf10b (Dr5), Trp53 (p53), Trp73, Zmat3
Cell Cycle
Ccng1, Cdc25a, Cdc25c, Cdkn1a (p21Cip1, Waf1), E2f1, E2f3, Mdm2, Myc, Ppm1d (Wip1), Rb1, Rprm, Sesn2
DNA Damage & Repair
Brca1, Btg2, Egfr, Gadd45a, Pcna, Pttg1
Angiogenesis
Il6, Pten, Serpinb5 (Maspin)
Responses Downstream of p53 Signaling
Apoptosis
Apaf1, Bag1, Bcl2, Bid, Birc5, Bnip3, Casp2, Casp9, Cradd, Cul9, Dapk1, Fadd, Fasl, Mcl1, Nf1, Nfkb1, Rela, Traf1, Wt1
Cell Cycle
Ccnb1, Ccne1, Ccng1, Ccnh, Cdk1 (Cdc2), Cdk4, Prc1
DNA Damage & Repair
Apex1, Brca2, Ercc1, Lig4, Mlh1, Xrcc4, Xrcc5
Transcription Factors & Regulators
Brca2, Egr1, Hif1a, Jun, Myod1, Nfkb1, Rela, Stat1
Other Responses Downstream of p53 Signaling
Kras