Target List
ATM / ATR Signaling
Atm, Atr, Brca1, Cdc25a, Chek1, Chek2 (Rad53), Fancd2, H2afx, Hus1, Mdc1, Parp1, Parp2, Rad1, Rad17, Rad50, Rad9a, Rnf8, Smc1a, Topbp1, Trp53 (p53)
DNA Damage & Repair
Nucleotide Excision Repair (NER)
Brca2, Ddb2, Dclre1a, Ercc1, Ercc2 (Xpd), Fancc, Lig1, Nthl1, Ogg1, Pcna, Pole, Rpa1, Trp53 (p53), Xpa, Xpc
Base Excision Repair (BER)
Apex1, Fen1, Lig1, Mbd4, Mpg, Nthl1, Ogg1, Parp1, Parp2, Pcna, Pole, Trp53 (p53), Ung, Xrcc1, Wrn
Mismatch Repair (MMR)
Abl1, Exo1, Mlh1, Mlh3, Msh2, Msh3, Pcna, Pms2
Double-Strand Break (DSB) Repair
Atm, Blm, Brca1, Brca2, Chek1, H2afx, Hus1, Lig1, Mdc1, Mlh1, Mre11a, Nbn (Nbs1), Prkdc, Rad50, Rad51, Rad52, Rpa1, Trp53bp1, Xrcc2, Xrcc6
Other DNA Repair Genes
Atr, Atrx, Brip1, Chek2 (Rad53), Fanca, Fancd2, Fancg, Gadd45a, Gadd45g, Mgmt (Agt), Polh, Poli, Pttg1, Rad1, Rad17, Rad18, Rad21, Rad51c, Rad51b, Rad9a, Rev1, Rnf8, Smc1a, Smc3, Sumo1, Topbp1, Xrcc3
Apoptosis
Abl1, Atm, Bax, Brca1, Cdkn1a (p21Cip1, Waf1), Chek2 (Rad53), Ppp1r15a (Gadd34), Prkdc, Rad21, Rad9a, Terf1, Trp53 (p53)
Cell Cycle
Atm, Atr, Cdc25a, Cdc25c, Cdkn1a (p21Cip1, Waf1), Chek1, Chek2 (Rad53), Ddit3 (Gadd153, Chop), Mcph1, Mdc1, Mif, Ppm1d (Wip1), Ppp1r15a (Gadd34), Terf1, Trp53 (p53)