Target List
Insulin Signaling
Akt1, Foxa2, Gsk3b, Igf1, Igfbp1, Insr, Irs1, Mapk1 (Erk2), Mapk8 (Jnk1), Mtor, Pik3ca (p110-alpha), Pik3r1 (PI3KA), Pklr, Ppargc1a, Prkaa1 (Ampk), Ptpn1 (Ptp), Slc2a4 (Glut4), Socs3, Srebf1
Adipokine Signaling
Adipor1, Adipor2, Akt1, Cd36 (QuantiNova Symbol: RGD1565355), Irs1, Lepr, LOC103694380 (Tnf), Mapk8 (Jnk1), Mtor, Nfkb1, Ppara, Ppargc1a, Prkaa1 (Ampk), Rxra, Serpine1 (Pai-1), Slc2a1, Slc2a4 (Glut4), Socs3, Stat3
Non-Insulin Dependent Diabetes Mellitus
Gck, Insr, Irs1, LOC103694380 (Tnf), Mapk1 (Erk2), Mapk8 (Jnk1), Mtor, Pik3ca (p110-alpha), Pik3r1 (PI3KA), Pklr, Slc2a2, Slc2a4 (Glut4), Socs3, Xbp1
Metabolic Pathways
Carbohydrate Metabolism
Acly, G6pc, G6pd, Gck, Gsk3b, Mlxipl (QuantiNova Symbol: AABR07035839.1), Pck2, Pdk4, Pklr, Rbp4
Beta-Oxidation
Acadl, Acox1, Akt1, Cpt1a, Cpt2, Fabp1, Irs1, Mtor, Ppara
Cholesterol Metabolism & Transport
Abca1, Abcg1, Apoa1, Apob, Apoc3, Apoe, Cd36 (QuantiNova Symbol: RGD1565355), Cnbp, Cyp2e1, Cyp7a1, Hmgcr, Ldlr, Lepr, Nr1h2, Nr1h3, Nr1h4, Ppara, Ppard, Pparg, Prkaa1 (Ampk), Rxra, Srebf1, Srebf2
Other Lipid Metabolism & Transport Genes
Acaca, Acsl5, Acsm3, Dgat2, Fabp3, Fabp5, Fasn, Gk, Hnf4a, Lpl, Ppa1, Scd, Slc27a5
Oxidative Phosphorylation
Ndufb6, Ppa1
Inflammatory Response
Cebpb, Fas, Ifng, Il10, Il1b, Il6, LOC103694380 (Tnf), Nfkb1, Rxra
Apoptosis
Akt1, Casp3, Cebpb, Fas, LOC103694380 (Tnf), Mapk1 (Erk2), Mapk8 (Jnk1), Nfkb1, Pik3ca (p110-alpha), Pparg, Prkaa1 (Ampk), Rxra, Serpine1 (Pai-1), Socs3
Other Fatty Liver Genes
Transcription Factors
Taf3