IGF2BP1 Gene Summary [Human]

This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Details

Type
Protein Coding
Official Symbol
IGF2BP1
Official Name
insulin like growth factor 2 mRNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:28866]
Ensembl ID
ENSG00000159217
Bio databases IDs NCBI: 10642 Ensembl: ENSG00000159217
Aliases insulin like growth factor 2 mRNA binding protein 1, IGF II mRNA binding protein 1
Synonyms CRD-BP, D030026A21Rik, D11Moh40e, D11Moh45, IMP-1, insulin-like growth factor 2 mRNA binding protein 1, LOC201194, mir-3063, Neilsen, VICKZ1, ZBP-1
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IGF2BP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RNA recognition motif (RRM) superfamily
  • transcription regulator
  • arCOG04150 universal archaeal KH domain protein
  • RNA recognition motif
  • mRNA binding
  • protein binding activity, bridging
  • K homology RNA-binding domain
  • protein binding
  • translation regulator
  • mRNA 3' UTR binding
  • mRNA 5' UTR binding
  • KH domain
  • K homology (KH) RNA-binding domain, type I

Pathways

Biological processes and signaling networks where the IGF2BP1 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • metastasis
  • cancer
  • neoplasia
  • breast cancer
  • mammary neoplasm
  • epithelial cancer
  • diabetes mellitus
  • tumorigenesis
  • non-insulin-dependent diabetes mellitus
  • lung adenocarcinoma
regulated by
role in cell
  • apoptosis
  • cell death
  • molecular cleavage in
  • cell viability
  • phosphorylation in
  • expression in
  • degradation in
  • proliferation
  • growth
  • differentiation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cytoplasmic mRNA processing body
  • cell periphery
  • Nucleus
  • cytosol
  • nucleoplasm
  • dendritic spines
  • growth cone
  • neurites
  • stress granule
  • filopodia
  • perikaryon
  • axons
  • dendrites
  • lamellipodia
  • paraspeckle-like structures

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human IGF2BP1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • positive regulation of cytoplasmic translation
  • negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • nervous system development
  • regulation of mRNA stability involved in response to stress
  • regulation of cytokine production
  • pallium cell proliferation in forebrain
  • negative regulation of translation
  • neuronal stem cell maintenance
  • CRD-mediated mRNA stabilization
  • mRNA transport

Cellular Component

Where in the cell the gene product is active
  • CRD-mediated mRNA stability complex
  • cytoplasmic stress granule
  • cytoplasmic mRNA processing body
  • neuronal cell body
  • nucleoplasm
  • growth cone
  • nucleus
  • perinuclear region of cytoplasm
  • cytoplasm
  • dendritic spine
  • cytosol
  • filopodium
  • lamellipodium

Molecular Function

What the gene product does at the molecular level
  • translation regulator activity
  • RNA binding
  • protein binding
  • mRNA 5'-UTR binding
  • mRNA binding
  • mRNA 3'-UTR binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.