Cd44 Gene Summary [Mouse]
Enables cargo receptor activity; hyaluronic acid binding activity; and type II transforming growth factor beta receptor binding activity. Contributes to cytokine binding activity and cytokine receptor activity. Involved in several processes, including hyaluronan catabolic process; negative regulation of T cell activation; and regulation of intracellular signal transduction. Acts upstream of or within several processes, including Wnt signaling pathway; morphogenesis of a branching epithelium; and wound healing involved in inflammatory response. Located in basolateral plasma membrane; external side of plasma membrane; and microvillus. Part of macrophage migration inhibitory factor receptor complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Orthologous to human CD44 (CD44 molecule (IN blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd44 |
| Official Name | CD44 antigen [Source:MGI Symbol;Acc:MGI:88338] |
| Ensembl ID | ENSMUSG00000005087 |
| Bio databases IDs | |
| Aliases | CD44 antigen |
| Synonyms | 216062 AT, CD44A, CD44 Antigen, CD44 (containing exon 5), Cd44i, CD44 molecule, CD44 molecule (IN blood group), CD44 STANDARD FROM, CDW44, CSPG8, ECM-III, ECMR-III, Epican, H-CAM, HCELL, HERMES, Hermes-1, Hermes antigen, HUTCH-1, HUTCH-I, IN, LHR, Ly-24, MC56, MDU2, MDU3, METAA, MIC4, NKT.44, Pgp-1, RHAMM |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd44 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MT1-MMP cleavage site
- extracellular domain
- punt binding
- stem region
- channel regulator
- cargo receptor activity
- protein kinase binding
- cytokine binding
- ectodomain
- epidermal growth factor receptor binding
- phosphoprotein binding
- hyaluronan binding domain
- Extracellular link domain
- protein binding
- ERM binding domain
- Link_Domain
- cytoplasmic domain
- ligand-binding domain
- transmembrane domain
- intracellular domain
- cytosolic tail domain
- cytokine receptor
- hyaluronic acid binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Cd44 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- asthma
- atopic dermatitis
- neoplasia
- superficial papillary bladder carcinoma
- nonmuscle invasive bladder cancer
- bladder carcinoma
- lymphomagenesis
- cancer
- hematologic cancer
phenotypes
- abnormal CD4-positive alpha beta T cell morphology
- abnormal CD4-positive alpha-beta T cell physiology
- abnormal CD8-positive alpha beta T cell morphology
- abnormal T-helper 1 physiology
- abnormal T-helper 2 physiology
- abnormal cell morphology
- abnormal cell physiology
- abnormal chemokine secretion
- abnormal circulating chemokine level
- abnormal circulating cytokine level
- abnormal definitive hematopoiesis
- abnormal digestive system physiology
- abnormal epidermal lamellar body morphology
- abnormal interleukin secretion
- abnormal involution of the mammary gland
- abnormal leukocyte adhesion
- abnormal leukocyte migration
- abnormal lipid level
- abnormal miniature excitatory postsynaptic currents
- abnormal mitochondrial crista morphology
- abnormal neutrophil physiology
- abnormal osteoclast differentiation
- abnormal physiological neovascularization
- abnormal response to infection
- abnormal uterus morphology
- abnormal vascular endothelial cell morphology
- abnormal vascular endothelial cell physiology
- abnormal vascular smooth muscle physiology
- abnormal vasculogenesis
- alopecia
- altered response to myocardial infarction
- choroidal neovascularization
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased T cell proliferation
- decreased activation-induced cell death of T cells
- decreased acute inflammation
- decreased alpha-beta T cell number
- decreased angiogenesis
- decreased blood urea nitrogen level
- decreased central memory CD4-positive alpha-beta T cell number
- decreased central memory CD8 positive alpha-beta T cell number
- decreased cholesterol level
- decreased circulating creatinine level
- decreased circulating tumor necrosis factor level
- decreased effector memory CD4-positive alpha-beta T cell number
- decreased fibroblast proliferation
- decreased mast cell histamine storage
- decreased mast cell number
- decreased myocardial infarction size
- decreased sensitivity to induced cell death
- decreased susceptibility to experimental autoimmune encephalomyelitis
- decreased susceptibility to induced arthritis
- decreased susceptibility to kidney reperfusion injury
- decreased susceptibility to type IV hypersensitivity reaction
- decreased transforming growth factor level
- decreased tumor growth/size
- delayed wound healing
- enhanced coordination
- impaired leukocyte tethering or rolling
- impaired macrophage phagocytosis
- impaired natural killer cell mediated cytotoxicity
- impaired neutrophil recruitment
- impaired skin barrier function
- impaired wound healing
- increased acute inflammation
- increased circulating interferon-gamma level
- increased circulating interleukin-2 level
- increased circulating tumor necrosis factor level
- increased diameter of tibia
- increased interleukin-1 beta secretion
- increased interleukin-10 secretion
- increased interleukin-6 secretion
- increased mean systemic arterial blood pressure
- increased mitochondria size
- increased sensitivity to induced morbidity/mortality
- increased susceptibility to induced arthritis
- increased susceptibility to parasitic infection
- increased tumor necrosis factor secretion
- liver inflammation
- lung inflammation
- no abnormal phenotype detected
- peritoneal inflammation
- short tibia
- thin epidermis
role in cell
- inhibition in
- expression in
- binding in
- growth
- aggregation in
- accumulation in
- activation in
- extension
- proliferation
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble fractions
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- cell surface
- cell periphery
- intracellular space
- perinuclear region
- postsynaptic region
- microvesicles
- membrane surface
- cellular membrane
- Nucleus
- vesicles
- Golgi Apparatus
- actin filaments
- intercellular junctions
- desmosomes
- secretory granule membrane
- cytoplasmic aggregates
- cytosol
- apical cell surfaces
- basolateral cell surfaces
- cytoplasmic face of plasma membrane
- plasma membrane extracellular face
- apical membrane
- uropod
- plasma membrane projections
- basolateral membrane
- cell membrane-lagging edges
- ruffled borders
- perinuclear vesicles
- extracellular matrix
- membrane rafts
- cellular protrusions
- microvilli
- filopodia
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd44 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wound healing, spreading of cells
- cell-matrix adhesion
- negative regulation of DNA damage response, signal transduction by p53 class mediator
- regulation of lamellipodium morphogenesis
- T cell activation
- cellular response to fibroblast growth factor stimulus
- cell adhesion
- positive regulation of monocyte aggregation
- inflammatory response
- cytokine-mediated signaling pathway
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of apoptotic process
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of heterotypic cell-cell adhesion
- monocyte aggregation
- cell migration
- positive regulation of peptidyl-tyrosine phosphorylation
- hyaluronan catabolic process
- positive regulation of peptidyl-serine phosphorylation
- cartilage development
Cellular Component
Where in the cell the gene product is active
- macrophage migration inhibitory factor receptor complex
- Golgi apparatus
- cell projection
- plasma membrane
- cell surface
- secretory granule membrane
- extracellular vesicular exosome
- focal adhesion
- microvillus
- cytosol
- basolateral plasma membrane
- apical plasma membrane
- lamellipodium membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- collagen binding
- hyaluronic acid binding
- cytokine receptor activity