Chd1 Gene Summary [Mouse]
Predicted to enable several functions, including ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; and methylated histone binding activity. Acts upstream of or within chromatin remodeling. Predicted to be located in cytoplasm. Predicted to be active in chromatin and nucleus. Is expressed in early conceptus and primary oocyte. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma and prostate cancer. Orthologous to human CHD1 (chromodomain helicase DNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chd1 |
| Official Name | chromodomain helicase DNA binding protein 1 [Source:MGI Symbol;Acc:MGI:88393] |
| Ensembl ID | ENSMUSG00000023852 |
| Bio databases IDs | |
| Aliases | chromodomain helicase DNA binding protein 1 |
| Synonyms | 4930525N21Rik, chromodomain helicase DNA binding protein 1, DNABP1, PILBOS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin organization modifier domain
- CDH1/2 SANT-Helical linker 1
- histone binding
- protein binding activity, bridging
- SNF2-related domain
- helicase superfamily c-terminal domain
- enzyme
- protein binding
- Helicase conserved C-terminal domain
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- Domain of unknown function (DUF4208)
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- Class II histone deacetylase complex subunits 2 and 3
- DEAD-like helicases superfamily
- Chromo (CHRromatin organization MOdifier) domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nasopharyngeal cancer
- metastasis
- gastric cancer
- high risk breast cancer
- cancer
- neoplasia
- plasma cell myeloma
- breast cancer
- aggressive B cell non-Hodgkin lymphoma
- invasive breast cancer
role in cell
- expression in
- quantity
- proliferation
- apoptosis
- colony formation
- clonogenicity
- differentiation
- reactivation in
- invasiveness
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation by host of viral transcription
- nucleosome organization
- chromatin remodeling
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear chromosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- protein binding
- histone binding
- methylated histone residue binding
- helicase activity
- chromatin binding