Itch Gene Summary [Mouse]
Enables ligase activity. Involved in several processes, including negative regulation of JNK cascade; negative regulation of NF-kappaB transcription factor activity; and protein K48-linked ubiquitination. Acts upstream of or within several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of T cell anergy; and positive regulation of protein catabolic process. Located in several cellular components, including cell cortex; cytoplasmic vesicle; and nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human ITCH (itchy E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Itch |
| Official Name | itchy, E3 ubiquitin protein ligase [Source:MGI Symbol;Acc:MGI:1202301] |
| Ensembl ID | ENSMUSG00000027598 |
| Bio databases IDs | |
| Aliases | itchy, E3 ubiquitin protein ligase |
| Synonyms | 6720481N21Rik, 8030492O04RIK, A130065M08, ADMFD, AIF4, AIP4, C230047C07RIK, itchy E3 ubiquitin protein ligase, itchy, E3 ubiquitin protein ligase, NAPP1, Ubiquitin-Protein Ligase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itch often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- Domain Homologous to E6-AP Carboxyl Terminus with
- WW class I binding domain
- enzyme binding
- linker domain
- enzyme
- protein binding
- proline rich domain
- WW domain
- HECTc
- Domain with 2 conserved Trp (W) residues
- ubiquitin-like protein transferase activity
- ligase
- WW class II binding domain
- ubiquitin-protein transferase activity
- WW
- ribonucleoprotein binding
- hinge domain
- Protein kinase C conserved region 2 (CalB)
- CXCR chemokine receptor binding
- C2 domain
Pathways
Biological processes and signaling networks where the Itch gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metabolic syndrome X
- coronary artery disease
- pancreatic cancer
- syndromic multisystem autoimmune disease
- neuroticism
- organismal death
- survival
- endocrine system disorder
- autoimmune disease
role in cell
- chemotaxis
- apoptosis
- growth
- migration
- phosphorylation in
- expression in
- proliferation
- cell death
- binding in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- perinuclear region
- cellular membrane
- cell cortex
- Plasma Membrane
- cytosol
- trans Golgi network
- cis Golgi networks
- endosomal membrane
- nucleoplasm
- nuclear envelope
- recycling endosomes
- early endosomes
- late endosomes
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Itch gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- regulation of necroptosis
- inflammatory response
- CD4-positive, alpha-beta T cell proliferation
- protein K29-linked ubiquitination
- apoptotic process
- defense response to virus
- protein autoubiquitination
- negative regulation of type I interferon production
- negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
- protein K48-linked ubiquitination
- negative regulation of NF-kappaB transcription factor activity
- positive regulation of protein catabolic process
- regulation of protein deubiquitination
- negative regulation of JNK cascade
- T cell anergy
- protein monoubiquitination
- ubiquitin-dependent protein catabolic process
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of receptor catabolic process
- positive regulation of T cell anergy
- regulation of cell growth
- innate immune response
- negative regulation of apoptotic process
- protein K63-linked ubiquitination
- negative regulation of CD4-positive, alpha-beta T cell proliferation
- receptor internalization
- negative regulation of defense response to virus
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- nucleoplasm
- early endosome membrane
- early endosome
- extracellular vesicular exosome
- cytoplasm
- cell cortex
- intracellular membrane-bounded organelle
- membrane
- mitochondrion
- cytosol
- cytoplasmic vesicle
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- ribonucleoprotein complex binding
- CXCR chemokine receptor binding
- small conjugating protein ligase binding
- small conjugating protein ligase activity
- ligase activity