Tnfrsf8 Gene Summary [Mouse]
Predicted to enable protease binding activity. Predicted to be involved in positive regulation of TRAIL production; positive regulation of apoptotic process; and positive regulation of tumor necrosis factor production. Predicted to be located in nucleoplasm and plasma membrane. Is expressed in several structures, including adrenal gland; brain; intestine; reproductive system; and thymus. Orthologous to human TNFRSF8 (TNF receptor superfamily member 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfrsf8 |
| Official Name | tumor necrosis factor receptor superfamily, member 8 [Source:MGI Symbol;Acc:MGI:99908] |
| Ensembl ID | ENSMUSG00000028602 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor receptor superfamily, member 8 |
| Synonyms | CD30, D1S166E, Ki, Ki-1, TNF receptor superfamily member 8, tumor necrosis factor receptor superfamily, member 8, tumour necrosis factor receptor superfamily, member 8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfrsf8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- traf2 binding domain
- extracellular domain
- TRAF binding domain
- protease binding
- cytoplasmic domain
- intracellular domain
- TNFR/NGFR cysteine-rich region
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Sézary syndrome
- mycosis fungoides
- cutaneous T-cell lymphoma
- atopic dermatitis
- diffuse large B-cell lymphoma
- asthma
- recurrent cutaneous T-cell lymphoma
- nodular lymphocyte predominance Hodgkin disease
- cutaneous large cell lymphoma
- CD30 positive anaplastic large cell lymphoma
role in cell
- apoptosis
- growth
- expression in
- proliferation
- cellular infiltration by
- activation in
- production in
- phosphorylation in
- number
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- nucleoplasm
- membrane rafts
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfrsf8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of TRAIL production
- cellular response to mechanical stimulus
- signal transduction
- negative regulation of cell proliferation
- positive regulation of apoptotic process
- positive regulation of tumor necrosis factor production
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protease binding