Lrp1b Gene Summary [Mouse]
Enables low-density lipoprotein particle receptor activity. Acts upstream of or within in utero embryonic development. Located in membrane. Is expressed in several structures, including adrenal medulla; central nervous system; and eye. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung disease (multiple); and melanoma. Orthologous to human LRP1B (LDL receptor related protein 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Lrp1b |
| Official Name | low density lipoprotein-related protein 1B [Source:MGI Symbol;Acc:MGI:2151136] |
| Ensembl ID | ENSMUSG00000049252 |
| Bio databases IDs | |
| Aliases | low density lipoprotein-related protein 1B |
| Synonyms | 9630004P12Rik, AABR07051892.1, LDL receptor related protein 1B, low density lipoprotein-related protein 1B, LRP-DIT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrp1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Complement Clr-like EGF-like
- Low-density lipoprotein receptor repeat class B
- protein binding
- NHL repeat unit of beta-propeller proteins
- EGF_CA
- ligand-binding domain
- transmembrane domain
- LDLa
- intracellular domain
- EGF domain
- cytosolic tail domain
- low-density lipoprotein receptor
- Low-density lipoprotein-receptor YWTD domain
- transmembrane receptor
- Coagulation Factor Xa inhibitory site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- prostatic carcinoma
- plasma cell myeloma
- asthma
- prostate cancer
- acute myeloid leukemia
- chronic lymphocytic leukemia
- major depression
- insomnia
role in cell
- expression in
- proliferation
- invasion by
- migration
- quantity
- growth
- accumulation in
- upregulation in
- neuroprotection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrp1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- low-density lipoprotein receptor activity