Csde1 Gene Summary [Mouse]
Enables RISC complex binding activity. Predicted to be involved in IRES-dependent viral translational initiation; regulation of gene expression; and stress granule assembly. Located in mitochondrial inner membrane. Is expressed in several structures, including limb; liver; lung; small intestine; and testis. Orthologous to human CSDE1 (cold shock domain containing E1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Csde1 |
| Official Name | cold shock domain containing E1, RNA binding [Source:MGI Symbol;Acc:MGI:92356] |
| Ensembl ID | ENSMUSG00000068823 |
| Bio databases IDs | |
| Aliases | cold shock domain containing E1, RNA binding |
| Synonyms | cold shock domain containing E1, cold shock domain containing E1, RNA binding, D1S155E, D3Jfr1, LOC100362464, mKIAA0885, NRAS-RELATED, UNR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Csde1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S1_like
- mRNA binding
- ribonucleoprotein binding
- enzyme
- protein binding
- Cold shock protein domain
- RNA binding
- SUZ-C motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute graft-vs-host disease
- breast cancer
- autism
- hereditary disorder
- growth failure
- complex neurodevelopmental disorder
role in cell
- expression in
- migration
- binding in
- proliferation
- number
- invasion
- size
- assembly
- replication in
- abnormality
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Csde1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stress granule assembly
- male gonad development
- positive regulation of cytoplasmic translation
- negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- regulation of translational initiation
- nuclear-transcribed mRNA catabolic process, no-go decay
- CRD-mediated mRNA stabilization
Cellular Component
Where in the cell the gene product is active
- CRD-mediated mRNA stability complex
- cytoplasmic stress granule
- cytoplasmic mRNA processing body
- cytosol
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- RNA stem-loop binding