Target List
AKT & PI3 Kinase Family Members & Their Regulators
Akt1, Akt2, Akt3, Btk, Grb10, Grb2, Hspb1 (Hsp27), Ilk, Mtcp1, Pdk2, Pdpk1, Pik3ca (p110alpha), Pik3cg, Pik3r1 (p85alpha), Pik3r2 (p85beta), Prkca, Prkcb, Prkcz, Pten, Tcl1
IGF-1 Signaling
Csnk2a1, Elk1, Fos, Grb2, Hras, Igf1, Igf1r, Irs1, Jun, Map2k1 (Mek1), Mapk3 (Erk1), Mapk8 (Jnk1), Ptpn11, Raf1, Rasa1, Shc1, Sos1, Srf
GSK3 Inactivation & β-Catenin Accumulation
Adar, Akt1, Apc, Ccnd1, Cd14, Ctnnb1, Eif2ak2, Gja1 (Cx43), Gsk3b, Irak1, Myd88, Nfkb1, Pdk1, Tirap, Tlr4, Tollip
Cytoskeleton Regulators
Cdc42, Pak1, Pdgfra, Rac1, Rhoa, Wasl
PTEN-Dependent Cell Cycle Arrest & Apoptosis
Akt1, Cdkn1b (p27Kip1), Fasl, Foxo3, Grb2, Ilk, Itgb1, Mapk1 (Erk2), Mapk3 (Erk1), Pdk1, Pdk2, Pten, Ptk2 (Fak), Rbl2, Shc1, Sos1
BAD Phosphorylation & Anti-Apoptotic Pathways
Akt1, Bad, Grb2, Hras, Igf1r, Irs1, Map2k1 (Mek1), Mapk1 (Erk2), Mapk3 (Erk1), Rps6ka1, Shc1, Sos1, Ywhah
mTOR Signaling
Akt1, Eif4b, Eif4e, Eif4ebp1, Eif4g1, Fkbp1a (Fkbp12), Mtor, Pdk1, Pdk2, Pten, Rheb, Rps6kb1, Tsc1, Tsc2
Regulation of eIF4e & p70 S6 Kinases
Akt1, Eif4e, Eif4ebp1, Eif4g1, Mtor, Irs1, Mapk1 (Erk2), Mapk14 (p38alpha), Mapk3 (Erk1), Pabpc1, Pdk1, Pdk2, Prkca, Pten, Rps6kb1
Other AKT Signaling Genes
Casp9, Chuk (IKBKA), Foxo1, Nfkbia (Iκbα, Mad3)