Mark2 Gene Summary [Mouse]
Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and tau protein binding activity. Predicted to be involved in several processes, including generation of neurons; protein phosphorylation; and regulation of neuron projection development. Located in basal cortex and nucleus. Is active in glutamatergic synapse and postsynapse. Is expressed in brain; early conceptus; and oocyte. Orthologous to human MARK2 (microtubule affinity regulating kinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mark2 |
| Official Name | MAP/microtubule affinity regulating kinase 2 [Source:MGI Symbol;Acc:MGI:99638] |
| Ensembl ID | ENSMUSG00000024969 |
| Bio databases IDs | |
| Aliases | MAP/microtubule affinity regulating kinase 2 |
| Synonyms | AU024026, Emk, EMK-1, LOC60328, MAP/microtubule affinity regulating kinase 2, microtubule affinity regulating kinase 2, PAR-1, Par-1b |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mark2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- aPKC binding domain
- central domain
- protein binding
- magnesium ion binding
- Protein kinase domain
- activation loop
- phosphorylation site
- kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Tau-protein kinase
- Protein Kinases, catalytic domain
- tau protein binding
- AMPKA_C_like
- spacer domain
- Kinase associated domain 1
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Mark2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- hypoglycemia
- weight gain
- splenomegaly
- pervasive developmental disorder
- proteinuria
- lymphadenopathy
- major depression
- glomerulonephritis
- growth failure
phenotypes
- abnormal CD4-positive alpha beta T cell morphology
- abnormal eating behavior
- abnormal glomerular capillary morphology
- abnormal glucose homeostasis
- abnormal humoral immune response
- abnormal immune system physiology
- abnormal spleen B cell follicle morphology
- decreased B cell proliferation
- decreased IgG3 level
- decreased IgM level
- decreased body length
- decreased body weight
- decreased brown adipose tissue amount
- decreased circulating adiponectin level
- decreased circulating cholesterol level
- decreased circulating insulin level
- decreased circulating insulin-like growth factor I level
- decreased circulating leptin level
- decreased circulating progesterone level
- decreased circulating prolactin level
- decreased circulating triglyceride level
- decreased corpora lutea number
- decreased embryo weight
- decreased epididymis weight
- decreased litter size
- decreased ovary weight
- decreased percent body fat/body weight
- decreased seminal vesicle weight
- decreased susceptibility to diet-induced obesity
- decreased susceptibility to hepatic steatosis
- decreased susceptibility to weight gain
- decreased testis weight
- decreased uterus weight
- decreased white adipose tissue amount
- enlarged heart
- enlarged lung
- enlarged lymph nodes
- enlarged spleen
- glomerulonephritis
- hemoglobinuria
- hypoglycemia
- improved glucose tolerance
- increased B cell number
- increased B cell proliferation
- increased adipocyte glucose uptake
- increased basal metabolism
- increased brain size
- increased energy expenditure
- increased insulin sensitivity
- increased interferon-gamma secretion
- increased interleukin-4 secretion
- increased prolactin level
- increased renal glomerulus lobularity
- increased spleen weight
- increased urine protein level
- infertility
- kidney inflammation
- lung inflammation
- lymph node hyperplasia
- mesangial cell hyperplasia
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- rectal prolapse
- reduced female fertility
- salivary gland inflammation
- small pituitary gland
- spleen hyperplasia
role in cell
- expression in
- accumulation
- phosphorylation in
- proliferation
- binding
- formation
- migration
- integrity
- growth
- stabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- cellular membrane
- focal adhesions
- Nucleus
- Plasma Membrane
- Mitochondria
- actin filaments
- microtubule bundles
- lateral plasma membrane
- nucleoplasm
- neurites
- actin stress fibers
- perikaryon
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mark2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of microtubule cytoskeleton organization
- protein autophosphorylation
- microtubule cytoskeleton organization
- protein phosphorylation
- mitochondrion degradation
- neuron migration
- regulation of axonogenesis
- regulation of cytoskeleton organization
- establishment or maintenance of epithelial cell apical/basal polarity
- establishment or maintenance of cell polarity regulating cell shape
- Wnt receptor signaling pathway
- activation of protein kinase activity
- establishment of cell polarity
- positive regulation of neuron projection development
- peptidyl-serine phosphorylation
- mitochondrion localization
- peptidyl-threonine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- dendrite
- lateral plasma membrane
- cytoplasm
- mitochondrion
- membrane
- actin filament
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- tau-protein kinase activity
- magnesium ion binding
- ATP binding
- protein binding
- RNA binding
- protein kinase activator activity
- cadherin binding
- tau protein binding
- lipid binding
- protein serine/threonine kinase activity