Target List
NFκB Signaling
Ikbkb (IKKbeta), Nfkb1, Nfkbia (Iκbα, Mad3), Rela, Tlr4
Cytokines
Ccl12 (MCP-5, Scya12), Ccl3 (Mip-1a), Ccl4 (Mip-1b), Ccl5 (Rantes), Cd40lg, Csf1 (Mcsf), Csf2 (GMCSF), Csf3 (Gcsf), Cxcl10 (Inp10), Cxcl12, Fasl, Il10, Il11, Il13, Il15, Il17a, Il18, Il1a, Il1b, Il2, Il21, Il22, Il23a, Il24, Il3, Il4, Il5, Il6, Il7, Il9, Lif, Lta (Tnfb), Osm, Tnf, Tnfsf10 (Trail), Tnfsf11 (Rankl)
IL6 / STAT3 Signaling
STAT3 Activators
Cxcl12, Egfr, Il10, Il11, Il17a, Il21, Il23a, Il6
Cell Surface Receptors
Cd4, Cd40, Cd80, Csf3r (G-CSFR), Cxcr4, Fas, Il18r1, Il1r1, Il2ra (Cd25), Il6ra, Il6st (Gp130), Lifr, Osmr, Tnfrsf10b (Dr5), Tnfrsf1a (Tnfr1), Tnfrsf1b
Signaling Upstream of IL6 / STAT3
Akt1, Jak2, Jak3, Map2k1 (Mek1), Mapk1 (Erk2), Mapk14 (p38alpha), Mapk3 (Erk1), Mapk8 (Jnk1), Mtor, Myc, Pias3, Rac1, Socs1, Socs3, Src, Tyk2
Signaling Downstream of IL6 / STAT3
Bax, Bcl2, Cdc25a, Cdkn1a (p21Cip1, Waf1), Hgf, Met, Pim1, Stat3
IL6 / STAT3 Signaling Target Genes
Ccl12 (MCP-5, Scya12), Ccl5 (Rantes), Cd80, Cebpd, Cxcl10 (Inp10), Cxcl12, Il10, Il11, Il12a, Il17a, Il1b, Il21, Il6, Myc, Socs3