Target List
Bone Remodeling & BMP Signaling
Adcy10, Alox12, Alox15, Alox5, Alpl, Bglap, Bmp2, Clcn7, Col1a1, Col1a2, Comt, Crtap, Ctsk, Enpp1, Hsd11b1, Igf1, Itga1, Itgb3, Mmp2, Mthfr, Nfatc1, Nog, Nos3 (eNOS), P2rx7, Plod2, Runx2, Sfrp1, Sost, Sparc, Spp1, Stat1, Timp2, Twist1, Wnt10b, Wnt3a
Calciotropic Hormones & Receptors
Ar, Calca, Calcr, Casr, Cyp17a1, Cyp19a1, Dbp, Esr1 (Erα), Esr2 (Erβ), Esrra, Nr3c1 (GR), Prl, Pth, Pth1r, Pthlh, Shbg, Tshr, Vdr
Cytokines, Growth Factors & Receptors
Bmp2, Bmp7, Cd40, Cnr2, Fgfr1, Fgfr2, Ghrh, Igfbp2, Il15, Il6, Il6ra, P3h1, Lrp1, Lrp5, Lrp6, Lta (Tnfb), Ltbp2, Mstn, Npy, Tgfb1, Tnfaip3, Tnfrsf11a (Rank), Tnfrsf11b (Opg), Tnfrsf1b, Tnfsf11 (Rankl), Vegfa
Osteoblast Activity & Differentiation
Alpl, Bglap, Bmp2, Runx2
RANK / RANKL / OPG Signaling
Tnfrsf11a (Rank), Tnfrsf11b (Opg), Tnfsf11 (Rankl)
WNT / β-Catenin Signaling
Dkk1, Lrp1, Lrp5, Lrp6, Sfrp4, Sost, Twist1, Wnt10b, Wnt3a
Other Osteoporosis Genes
Acp5, Car2, Lep (Leptin), Mab21l2