Target List
Induction of Apoptosis
Death Domain Receptors
Casp8ap2, Diablo (Smac), Fadd, LOC103694380 (Tnf), Tnfrsf10b (QuantiNova Symbol: AABR07018323.1)
DNA Damage & Repair
Cidea, Cideb, LOC100909750 (Abl1), Tp53 (p53), Tp73
Extracellular Apoptotic Signals
Casp8ap2, Cflar (Casper), Dapk1
Other Pro-Apoptotic Genes
Akt1, Apaf1, Bad, Bak1, Bax, Bcl10, Bcl2l11, Bid, Bik, Bnip3, Bok, Casp1 (Ice), Casp12, Casp14, Casp2, Casp3, Casp4, Casp8 (Flice), Cycs, Dffa, Dffb, Fas, Faslg, Gadd45a, LOC103689977 (Casp6), Lta (Tnfb), Mapk1 (Erk2), Pycard (Tms1, Asc), Tnfsf10 (Trail), Tp53bp2, Tp63, Tradd, Traf3
Anti-Apoptotic
Akt1, Anxa5, Api5, Aven, Bag1, Bax, Bcl2, Bcl2a1 (Bfl-1, A1), Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l2, Birc3 (c-IAP1), Birc5, Bnip2, Bnip3, Cd40lg, Cflar (Casper), Dad1, Dapk1, Faim, Fas, Il10, LOC103694380 (Tnf), Mapk8ip1 (JIP1), Naip6 (QuantiNova Symbol: AC135826.1), Nfkb1, Nol3, Polb, Prdx2, Prlr, Sphk2, Xiap
Regulation of Apoptosis
Negative Regulation of Apoptosis
Anxa5, Bag1, Bcl10, Bcl2, Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l2, Bfar, Birc2 (c-IAP2), Birc3 (c-IAP1), Bnip2, Bnip3, Card10, Casp3, Cd40lg, Cflar (Casper), Cidea, Dapk1, Dffa, Fas, Nol3, Tp53 (p53), Tp73, Xiap
Positive Regulation of Apoptosis
Bad, Bak1, Bax, Bid, Bnip3, Casp1 (Ice), Casp14, Casp2, Casp4, Casp8 (Flice), Cd40, Cideb, Fadd, Faslg, LOC100909750 (Abl1), LOC103689977 (Casp6), LOC103694380 (Tnf), Ltbr, Nod1, Pycard (Tms1, Asc), Ripk2, Tnfrsf10b (QuantiNova Symbol: AABR07018323.1), Tnfsf10 (Trail), Tnfsf12, Tp53 (p53), Tp53bp2, Traf2, Traf3
Death Domain Receptors
Dapk1, Fadd, Nfkb1, Tnfrsf10b (QuantiNova Symbol: AABR07018323.1), Tnfrsf11b (Opg), Tnfrsf1a (Tnfr1), Tnfrsf1b, Tradd
Caspases & Regulators
Caspases
Casp1 (Ice), Casp12, Casp14, Casp2, Casp3, Casp4, Casp7, Casp8 (Flice), Casp9, Cflar (Casper), LOC103689977 (Casp6), Pycard (Tms1, Asc)
Caspase Activation
Aifm1, Bax, Casp1 (Ice), Casp8ap2, Casp9, Nod1, Pycard (Tms1, Asc), Tnfrsf10b (QuantiNova Symbol: AABR07018323.1), Tp53 (p53)
Caspase Inhibition
Birc5, Xiap