Target List
Vasodilation
Ace, Ace2, Adm, Adrb1, Agtr1a, Agtr1b, Agtr2, Calca, Cps1, Ednrb, Ephx2, Gch1, Kcnj8, Kng1, Nos3 (eNOS), Nppb, Nppc, Npr1, P2rx4, Pde5a
Vasoconstriction
Ace, Ace2, Adm, Adra1b, Agt, Agtr1a, Agtr1b, Alox5, Avp, Avpr1a, Bdkrb2, Bmpr2, Cacna1c, Cav1, Ece1, Edn1, Edn2, Ednra, Ednrb, Nppc, Npy1r, Ptgs1 (Cox1), Ptgs2 (Cox2), Uts2r
Vasotone
Agtr1a, Agtr1b, Drd3, Nos3 (eNOS), Nppb, Nppc, Ren1
Smooth Muscle Contraction
Acta2 (α-SMA), Adra1b, Adrb1, Bdkrb2, Cacna1c, Cav1, Edn1, Edn2, Ednra, Ednrb, Kcnma1, Kng1, P2rx4, Ptgs1 (Cox1), Ptgs2 (Cox2), Uts2
Smooth Muscle Relaxation
Gucy1a1, Kcnma1, P2rx4
Myosin Light Chain Kinases
Mylk, Mylk2
Blood Pressure Regulation
Ace, Ace2, Acta2 (α-SMA), Agt, Agtr2, Avp, Avpr1a, Avpr1b, Bdkrb2, Cacna1c, Calca, Drd3, Drd5, Ece1, Edn1, Edn2, Ednrb, Ephx2, Gch1, Gucy1a1, Nos3 (eNOS), Nppb, Nppc, Npr1, Npy1r, P2rx4, Ptgs1 (Cox1), Ptgs2 (Cox2), Ren1, Uts2, Uts2r
Renin-Angiotensin System
Ace, Ace2, Agt, Agtr1a, Agtr1b, Ece1, Ren1
Nitric Oxide Signaling
Agt, Agtr2, Gucy1a1, Gucy1b1, Nosip, Nostrin
Nitric Oxide Metabolism
Agtr2, Arg2, Cav1, Cps1, Edn1, Gch1, Gchfr, Hif1a, Nos3 (eNOS), P2rx4
Cyclic-GMP Synthesis & Signaling
Adra1d, Gucy1b1, Pde3b, Prkg1, Prkg2, Ptgir, S1pr1
Osmotic Stress
Agt, Avp, Avpr1b, Bdkrb2, Kcnma1
Hypoxia Signaling
Ace, Adm, Cav1, Ece1, Edn1, Ednra, Hif1a, Kcnma1, Nos3 (eNOS), Nppc, Pde5a
Secondary Messenger-Mediated Signaling
Adra1d, Pde3b, Ptgir, S1pr1, Sphk1
Ion Transport
Atp2c1, Atp6ap2, Bdkrb1, Chrna1, Chrnb1, Clic1, Clic4, Clic5, Cnga1, Cnga2, Cnga3, Cnga4, Cngb1, Cngb3, Itpr1, Itpr2, Plcg2, Scnn1a, Scnn1b, Scnn1g, Slc7a1
Lipid Metabolism
Pde3a, Pde3b, Plcg1, Plcg2, Sphk1, Sphk2