Target List
Up-Regulated in Hepatocellular Carcinoma
Bcl2, Birc5, Ccnd1, Cflar (Casper), Fzd7, Igf2, Irs1, Lef1, Mcl1, Met, Nfkb1, Pin1, Ptk2 (Fak), Rac1, Rhoa, Smad7, Stat3, Tcf4, Tgfa, Tgfb1, Tnfsf10 (Trail), Xiap
Down-Regulated in Hepatocellular Carcinoma
Bax, Bid, Casp8 (Flice), Cdkn1a (p21Cip1, Waf1), Cdkn2a (p16INK4a), Dlc1, Fadd, Fas, Hhip, Igfbp1, Igfbp3, Itgb1, Pten, Rb1, Smad4, Socs1, Socs3, Tgfbr2, Tnfrsf10b (Dr5)
Signal Transduction
Classical WNT Signaling
Ccnd1, Cdkn2a (p16INK4a), Ctnnb1, Fzd7, Lef1, Mtdh, Pin1, Rb1, Sfrp2, Tcf4
TGFβ Signaling
Smad4, Smad7, Tgfb1, Tgfbr2
AKT & PI3 Kinase Signaling
Akt1, Irs1, Pten
IGF / IGFR Signaling
Igf2, Igfbp1, Igfbp3, Irs1
Hippo Signaling
Yap1
RAS / RAF / MAP Kinase Signaling
Cdkn1a (p21Cip1, Waf1), Cdkn2a (p16INK4a), Dlc1, Hras, Nras, Rac1, Rassf1, Rb1, Rhoa, Trp53 (p53)
EGFR Signaling
Adam17 (Cd156b), Cdh13, Egf, Egfr, Tgfa, Tgfb1
MET / HGF Signaling
Met, Hgf
G-Protein Signaling
Cdh13, Cdkn1a (p21Cip1, Waf1), Cdkn2a (p16INK4a), Dab2ip, Dlc1, Hras, Nras, Rac1, Rassf1, Rb1, Reln, Rhoa, Trp53 (p53)
Epithelial-to-Mesenchymal Transition (EMT)
Ctnnb1, Hgf, Lef1, Smad4, Smad7, Tgfb1
Cell Cycle
Birc5, Ccnd1, Ccnd2, Cdkn1a (p21Cip1, Waf1), Cdkn1b (p27Kip1), Cdkn2a (p16INK4a), E2f1, Ep300, Gadd45b, Igf2, Myc, Pten, Rassf1, Runx3
Apoptosis
Bax, Bcl2, Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Bid, Birc2 (cIAP1, cIAP2), Birc5, Casp8 (Flice), Cflar (Casper), Dlc1, E2f1, Ep300, Fadd, Fas, Fhit, Gadd45b, Gstp1, Mcl1, Msh2, Pycard (Tms1, Asc), Runx3, Socs3, Tert, Tnfrsf10b (Dr5), Tnfsf10 (Trail), Wt1
Immune & Inflammatory Responses
Ccl5 (Rantes), Cxcr4, Nfkb1, Ptgs2 (Cox2), Rac1, Tgfb1, Tlr4
Extracellular Matrix (ECM) & Cell Adhesion Molecules
Adam17 (Cd156b), Akt1, Cdh1 (E-cadherin), Cdh13, Cflar (Casper), Dlc1, Egfr, Ep300, Hgf, Itgb1, Lef1, Opcml (Obcam), Pten, Pycard (Tms1, Asc), Rac1, Reln, Rhoa, Smad7, Socs1, Socs3, Tgfb1
Angiogenesis
Angpt2, Casp8 (Flice), Cdh13, Ctnnb1, Egf, Flt1 (Vegfr1), Kdr (Vegfr2), Pdgfra, Pten, Ptk2 (Fak), Tgfbr2, Vegfa
DNA Damage & Repair
Ccnd1, Cdkn1a (p21Cip1, Waf1), Msh2, Msh3, Trp53 (p53), Xiap