Target List
Inflammasomes
AIM2
Casp1 (Ice), Pycard (Tms1, Asc)
IPAF
Casp1 (Ice), Naip6 (QuantiNova Symbol: AC135826.1), Nlrc4 (Ipaf), Pycard (Tms1, Asc)
NLRP1
Casp1 (Ice), Nlrp1a (Nalp1)
NLRP3
Casp1 (Ice), Nlrp3, Pycard (Tms1, Asc)
Negative Regulation of Inflammasomes
Bcl2, Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Cd40lg, Ctsb, Hsp90aa1, Hsp90ab1, Hsp90b1, LOC103689974 (Tnfsf11), LOC103694380 (Tnf), Mefv, Pstpip1, Sugt1, Tnfsf14, Tnfsf4 (Ox40l)
Signaling Downstream of Inflammasomes
Ifng, Il12a, Il12b, Il18, Il1b, Il33, Irak1, Irf1, Mok, Myd88, P2rx7, Panx1, Ptgs2 (Cox2), Ripk2, Txnip
NOD-Like Receptors
NOD-Like Receptors
Ciita, Naip6 (QuantiNova Symbol: AC135826.1), Nlrc4 (Ipaf), Nlrp12, Nlrp1a (Nalp1), Nlrp3, Nlrp5, Nlrp6, Nlrx1, Nod2
Signaling Downstream of NOD-Like Receptors
Birc2 (c-IAP2), Birc3 (c-IAP1), Card6, Casp8 (Flice), Ccl11 (Eotaxin), Ccl12, Ccl2 (Mcp-1), Ccl5 (Rantes), Ccl7 (Mcp-3), Cflar (Casper), Chuk (Ikbka, Ikka), Cxcl1, Cxcl3, Fadd, Ifnb1, Ikbkb (IKK2), Ikbkg, Il6, Irf1, Irf2, Irf3, Irf4, Irf5, Irf6, LOC100910771 (Map3k7), LOC103694380 (Tnf), Mapk1 (Erk2), Mapk11 (p38beta), Mapk12 (Sapk3), Mapk13, Mapk14 (p38alpha), Mapk3 (ERK1), Mapk8 (Jnk1), Mapk9 (Jnk2), Nfkb1, Nfkbia (Iκbα, Mad3), Nfkbib (Trip9), Pea15, Rela, Ripk2, Sugt1, Tab1, Tab2, Tirap, Traf6, Xiap
Pro-Inflammatory Caspases
Casp1 (Ice), Casp12