Target List
Autophagy Machinery Components
Autophagic Vacuole Formation
Atg12, Atg4a, Atg4b, Atg5, Atg16, Atg6 (BECN1), Atg8a (GABARAP), Atg8b (GABARAPL1), Atg9 (ATG9A), ema (CLEC16A), Hmt-1 (ABCB6)
Vacuole Targeting
Atg4a, Atg4b, Atg8a (GABARAP), Atg8b (GABARAPL1)
Protein Transport
Atg10, Atg3, Atg4a, Atg4b, Atg7, Atg16, Atg8a (GABARAP), Atg8b (GABARAPL1), Atg9 (ATG9A), Dlc90F (DYNLT1)
Autophagosome-Lysosome Linkage
Lamp1, Atg8a (GABARAP), Atg8b (GABARAPL1), cac (CACNA1A), Ccz1, CG4025 (DRAM2), comt, Lerp, Npc1a (NPC1), NPC1b (NPC1)
Ubiquitination
Atg3, Atg7, HDAC6, DJ-1alpha (PARK7), dj-1beta (PARK7), park (PARK2)
Proteases
Atg4a, Atg4b, scny, Uba1
Other Autophagy Machinery Components
Atg1 (ULK2), Atg101, Atg13, Atg14, Atg17, Atg18a, Atg18b, Atg2 (ATG2B)
Regulation of Autophagy
Co-Regulators of Autophagy & Apoptosis
Akt1, app, Atg12, Atg5, cln3, Fadd, fas, htt, Mtor, Pten, Acn (ACIN1), AMPKalpha (PRKAA1, PRKAA2), Atg6 (BECN1), BI-1, Bruce (BIRC6), bsk (MAPK8), Buffy, CG4025 (DRAM2), CtsB1 (CTSB), Dcp-1 (CASP7), debcl (BOK), IP3K2 (ITPKA), p53 (TP53), park (PARK2), Pi3K59F (PIK3C3), Pi3K92E (PIK3CB), sesB (SLC25A4)
Co-Regulators of Autophagy & the Cell Cycle
Pten, p53 (TP53), Rbf (RBL2), Rbf2
Autophagy Induction by Intracellular Pathogens
Lamp1
Autophagy in Response to Other Intracellular Signals
Uvrag, BI-1, cathD (CTSD), CG1598 (ASNA1), CG4025 (DRAM2), desat1 (SCD5), drpr (MEGF11), eIF4G (EIF4G1), Hrs (HGS), kibra (WWC1), p38a (MAPK14), p38b (MAPK11), pcm (XRN1), Pi3K59F (PIK3C3), Pi3K92E (PIK3CB), S6k (RPS6KB1), Vps13 (VPS13A), Vps16A (VPS16), Vps28, Vps35, Vps39
Chaperone-Mediated Autophagy
Hsc70-1 (HSPA8), Hsp83 (HSP90AB1)
Other Autophagy Regulatory Gene
Atg1 (ULK2), Atg101, Atg13, Atg14, Atg17, Atg18a, Atg18b, Atg2 (ATG2B)
Other Autophagy Genes
Act5C (ACTA2), ctp, Pink1, Psn (PSEN1)