Target List
Parkin Complex
HSPA4, PARK7, STUB1
Parkin Substrate
ATXN2, ATXN3, GPR37, SYT11
Cell Adhesion Molecules
APC, APP, CDH8, FN1, NFASC, LOC490812, PTEN, TPBG
Ubiquitination
CDC27, CUL2, FBXO9, LRRK2, PAN2, SKP1, STUB1, UBA1, UBC, UBE2I, UBE2K, UBE2L3, UCHL1, USP34
Inflammation
FN1, PRDX2, YWHAZ
Apoptosis
Pro-Apoptotic
APC, APP, CASP3, CASP4, CASP8, CASP9, CUL2, MAPK9, PSEN2, PTEN
Anti-Apoptotic
APC, BDNF, CASP3, CASP9, NEFL, NR4A2, OPA1, PPID, PRDX2, PSEN2, PTEN, SLC25A4, SNCA, TCF7L2, YWHAZ
Mitochondrial Genes
CASP3, CASP7, CASP8, HSPA4, LRRK2, NEFL, OPA1, PARK7, PTEN, SLC25A4, SNCA, TH, UCHL1, VAMP1, VDAC3, YWHAZ
Synaptic Vesicles
LRRK2, SEPT5, SV2B, SYNGR3, SYT1, SYT11, TH
Signal Transduction
Dopaminergic Signaling
LOC479096, DDC, DRD2, HTR2A, NR4A2, PARK7, SEPT5, SLC6A3, SNCA, TH
GABAergic Signaling
DRD2, GABBR2
MAP Kinase Signaling
APC, FGF13, MAPK9, PRDX2, RGS4
Notch Signaling
APP, PSEN2
Cytoskeleton Regulators
APC, CDC42, MAPT, NEFL
Ion Transport
ATP2B2, CADPS, CXXC1, DRD2, EGLN1, GBE1, GRIA3, HTR2A, KCNJ6, NSF, PSEN2, S100B, SRSF7, SLIT1, SNCA, VDAC3
Transporters
ATP2B2
Channels & Transporters
GRIA3, SLC18A2, SLC6A3, SLC25A4, SV2B, SYT1, SYT11, VDAC3
Other Parkinson's Disease Genes
ALDH1A1 (RALDH1), BASP1, CHGB, CIRBP, DLK1, HMGCS1, NCOA1, NTRK2, PPP2R1B, RTN1