Target List
Up-Regulated in Cardiotoxicity
Muscle Contraction
Klhl41
Angiogenesis
Il6, Plau (uPA), Serpine1 (Pai-1), Tgfb2
Signal Transduction
Abra, Adra2a, Ccr1, Crem, Il6, Rnd1, Sik1, Tgfb2, Tiam1
Cell Cycle
Bcat1, Fosl1 (Fra-1), Hspa2, Sik1, Tgfb2
Cardiomyocyte Development
Btg2, Crem, Egr1, Fhl1, Hspa2, Il6, Rnd1, Sik1, Spp1, Tgfb2, Tiam1, Timp1, Ucp1, Vcan
Metabolism (Regulation & Mechanism)
Abra, Adra2a, Btg2, Ch25h, Crem, Egr1, Fosl1 (Fra-1), Il6, Pdk4, Pla2g4a, Pum2, Rbm3, Sik1, Tcf4, Tgfb2, Timp1
Cell Migration & Motility
Abhd2, Ccl7 (mcp3), Ccr1, Fosl1 (Fra-1), Il6, Plau (uPA), Ppbp, Pvr, Tgfb2
Other Genes Up-Regulated in Cardiotoxicity
Cd14, Cfd, Ckm, Fcgr2b, Gpm6a, Hamp, Klhl40, Mt1, Bpifa1, Reg3b, Tubb6, Uck2
Down-Regulated in Cardiotoxicity
Muscle Contraction
Acta1, Gja1 (Cx43), Kcnj12, Rps6kb1
Angiogenesis
Col15a1, Postn, Vegfa
Signal Transduction
Aifm1, Dusp8, Gja1 (Cx43), Igfbp5, Itpr2, Rps6kb1, S1pr2, Thrap3
Cell Cycle
Csnk2a2, Mcm6, Psma2, Psmd7, Txnip
Cardiomyocyte Development
Acta1, Col15a1, Col3a1, Gja1 (Cx43), Igfbp5, Pln, Rps6kb1, Sox4, Txnip
Metabolism (Regulation & Mechanism)
Ash1l, Atp5j, Dusp8, Igfbp5, Mcm6, Nfib, Ppp1r14c, Prkab2, S1pr2, Sox4, Thrap3, Txnip, Zfp148, Zfp612
Cell Migration & Motility
Igfbp5, Nexn, Rps6kb1
Other Genes Down-Regulated in Cardiotoxicity
Ak3, Bgn, Bsn, Hsph1, Ift20, Pkn2, Slc4a3, Uba5, Ubxn2a, Vim, Wipi1