Target List
Breast Cancer Classification Markers
Luminal A-C Breast Cancers
Esr1 (Erα), Foxa1, Gata3, Krt8, Krt18, Slc39a6, Tff3, Xbp1
HER2-Like Breast Cancers
Erbb2 (Her-2, neu), Grb7
Basal-Like / Triple Negative Breast Cancers
Birc5, Egfr, Krt5, Notch1
Breast Cancer Metastasis to Lung
Id1, Mmp2, Ptgs2 (Cox2)
Signal Transduction
Steroid Receptor-Mediated Signaling
Ar, Brca1, Ccne1, Ctnnb1, Esr1 (Erα), Esr2 (Erβ), Igf1, Krt19, Pgr, Rb1
Hedgehog Signaling
Bcl2, Ccnd1, Gli1, Snai2
Glucocorticoid Signaling
Igfbp3, Nme1 (Nm23a), Nr3c1 (GR)
Classical WNT Signaling
Apc, Ccnd1, Ctnnb1, Sfrp1
AKT & PI3 Kinase Signaling
Akt1, Erbb2 (Her-2, neu), Igf1, Igf1r, Pten
Notch Signaling
Birc5, Notch1
MAP Kinase Signaling
Mapk1 (Erk2), Mapk3 (Erk1), Mapk8 (Jnk1), Trp73
Epithelial-to-Mesenchymal Transition (EMT)
Ctnnb1, Notch1, Src, Tgfb1, Twist1
Angiogenesis
Cdh13, Ctnnb1, Egf, Erbb2 (Her-2, neu), Id1, Il6, Jun, Notch1, Plau (uPA), Pten, Serpine1 (Pai-1), Slit2, Thbs1 (TSP-1), Vegfa
Cell Adhesion Molecules
Adam23, Apc, Bcl2, Cdh1 (E-cadherin), Cdh13, Cdkn2a (p16INK4a), Csf1 (Mcsf), Ctnnb1, Egfr, Erbb2 (Her-2, neu), Pten, Tgfb1, Thbs1 (TSP-1)
Proteases
Adam23, Cst6, Ctsd, Mmp2, Mmp9, Plau (uPA), Pycard (Tms1, Asc)
Apoptosis
Akt1, Apc, Bad, Bcl2, Cdh1 (E-cadherin), Cdh13, Cdkn1a (p21Cip1, Waf1), Cdkn2a (p16INK4a), Gstp1, Igf1, Il6, Jun, Muc1 (mucin), Nme1 (Nm23a), Rarb, Sfn (14-3-3σ), Sfrp1, Trp53 (p53), Trp73, Twist1
Cell Cycle
Apc, Bcl2, Ccna1, Ccnd1, Ccnd2, Ccne1, Cdk2, Cdkn1a (p21Cip1, Waf1), Cdkn1c (p57Kip2), Cdkn2a (p16INK4a), Jun, Mki67, Myc, Pten, Rassf1, Rb1, Sfn (14-3-3σ), Trp53 (p53)
DNA Damage & Repair
Apc, Atm, Brca1, Brca2, Ccnd1, Cdkn1a (p21Cip1, Waf1), Mapk1 (Erk2), Mgmt (Agt), Mlh1, Sfn (14-3-3σ), Trp53 (p53), Trp73
Xenobiotic Transport
Abcb1a (Mdr1), Abcg2 (Bcrp)
Transcription Factors
Ar, Ctnnb1, Esr1 (Erα), Esr2 (Erβ), Foxa1, Gata3, Hic1, Jun, Myc, Notch1, Nr3c1 (GR), Pgr, Prdm2 (Riz1), Rarb, Rb1, Trp53 (p53), Trp73, Xbp1