Target List
Cytokines & Receptors
CCL5 (RANTES), CCR3, CCR4, CCR5, CCR6, CXCR3, IL10, IL12B, IL12RB2, IL13, IL13RA1, IL17A, IL17RE, IL18, IL18R1 (IL18RA), IL18RAP, IL1R2, IL1RL1, IL2, IL21, IL2RA, IL4, IL4R (CD124), IL5, IL6, IL6R, IL9, TNF
T Helper 1 Subtype Markers
CCR5, HAVCR2, IGSF6, IL12B, IL18, IRF1, SOCS1, SOCS5, TLR4, TLR6, TNF
T Helper 2 Subtype Markers
CCL5 (RANTES), CCR3, CCR4, CEBPB, ICOS, IL13RA1, IL4R (CD124), JAK1, NFATC2, NFATC2IP, PCGF2, PTGDR2
Transcription Factors
CEBPB, FOSL1, FOXP3, GATA3, GATA4, HOXA10, HOXA11, HOXA3, ID2, IRF4, IRF8, LOC100156637 (RORA), LOC100520325 (ZEB1), MAF, NFATC2, NFATC2IP, NR4A3, REL, RELB, RORC, RUNX1 (AML1), STAT1, STAT4, STAT6, TOX, ZBTB7B
Epigenetically Regulated Genes
Th1 Cells
IFNG, IL12RB2, IL18R1 (IL18RA), IL18RAP, FASLG (TNFSF6), TBX21
Th2 Cells
ASB2 (ASB2), GATA3, IL13, IL1RL1, IL4, IL5, PPARG
Th17 Cells
IL17A, IL17RE, IL21, LOC100156637 (RORA), RORC
Inducible & Natural Regulatory T (iTreg & nTreg) Cells
CCR6, FOSL1, FOXP3, IKZF2, IL9, IRF4, IRF8, MYB, NR4A3, REL, RELB, TGIF1, TNFSF11
Conventional Versus Regulatory T-Cells
CACNA1F, CHD7, FOXP3, GATA4, HOPX, HOXA10, HOXA11, HOXA3, ID2, IKZF2, IL1R2, IL2RA, KIF2C, LOC100520045 (FCMR), LOC100520325 (ZEB1), LRRC32, PKD2, TNFRSF9, TP53INP1, UTS2