Target List
Induction of Apoptosis
Death Domain Receptors
cradd, fadd, tnfb
DNA Damage & Repair
abl1, cideb, tp53, tp63, tp73
Extracellular Apoptotic Signals
cflara, dapk1
Other Pro-Apoptotic Genes
badb (BAD), baxb (BAX), bcl10, bcl2l11, bida (BID), bik, bnip1a (BNIP1), bnip3, bnip3lb (BNIP3L), boka (BOK), casp2, casp3a, casp6, casp8, caspa (CASP4), caspb (CASP4), caspbl, caspxa, cd27, cycsa (CYCS), dffa, dffb, diabloa (DIABLO), fas, faslg, gadd45aa (GADD45A), gadd45ab (GADD45A), lta, nod1, pycard, tnfrsf9b (TNFRSF9), tnfrsfa, tnfsf10, tp53bp2a (TP53BP2), tradd, traf3
Anti-Apoptotic
akt1, api5, bag1, bag3, baxb (BAX), bcl2a, bcl2l1, birc5a (BIRC5), birc6, bnip1a (BNIP1), bnip2, bnip3, bnip3lb (BNIP3L), braf, cd27, cd40lg, cflara, dad1, dapk1, faima (FAIM), fas, igf1rb (IGF1R), il10, mcl1a (MCL1), nfkb1, ripk2, tnfb, tp63, xiap
Regulation of Apoptosis
Negative Regulation of Apoptosis
bag1, bag3, bcl10, bcl2a, bcl2l1, birc2, birc6, bnip1a (BNIP1), bnip2, bnip3, bnip3lb (BNIP3L), braf, casp3a, cd27, cd40lg, cflara, dapk1, dffa, fas, igf1rb (IGF1R), mcl1a (MCL1), tp53, tp73, xiap
Positive Regulation of Apoptosis
abl1, akt1, badb (BAD), baxb (BAX), bcl2l11, bida (BID), bik, bnip3, bnip3lb (BNIP3L), casp2, casp6, casp8, caspa (CASP4), caspb (CASP4), caspbl, caspxa, cd40, cideb, cradd, fadd, faslg, lta, nod1, pycard, ripk2, tnfb, tnfrsf9b (TNFRSF9), tnfrsfa, tnfsf10, tnfsf12, tp53, tp53bp2a (TP53BP2), tradd, traf1, traf2a, traf3
Death Domain Receptors
cradd, dapk1, fadd, ripk1l (RIPK1), tnfrsf11a, tnfrsf11b, tnfrsf13b, tnfrsf17, tnfrsf18, tnfrsf19, tnfrsf1a, tnfrsf1b, tnfrsf21, tnfrsfa, tradd
Caspases & Regulators
Caspases
casp2, casp3a, casp6, casp7, casp8, casp9, caspa (CASP4), caspb (CASP4), caspbl, caspxa, cflara, cradd, pycard
Caspase Activation
aifm1, apaf1, baxb (BAX), casp9, nod1, pycard, tnfrsfa, tp53
Caspase Inhibition
cd27, xiap