CFLAR Gene Summary [Human]
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | CFLAR |
| Official Name | CASP8 and FADD like apoptosis regulator [Source:HGNC Symbol;Acc:HGNC:1876] |
| Ensembl ID | ENSG00000003402 |
| Bio databases IDs | |
| Aliases | CASP8 and FADD like apoptosis regulator |
| Synonyms | 2310024N18RIK, A430105C05Rik, AU021929, CASH, CASP8 and FADD-like apoptosis regulator, CASP8AP1, Caspase 8 associated, Casper, c-FLIP, CLARP, FLAME, FLAME-1, FLICE-LIKE IP, FLIP, Gm9845, I-FLICE, LOC102724614, MRIT |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CFLAR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death effector domain
- death receptor binding
- protease binding
- caspase-like domain
- nuclear localization sequence
- caspase homology domain
- protein binding
- protease activator
- enzyme activator activity
- CASc
- binding protein
- p12 domain
- protease like domain
- Death Domain Superfamily of protein-protein interaction domains
- protease-like domain
Pathways
Biological processes and signaling networks where the CFLAR gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- chronic lymphocytic leukemia
- breast carcinoma
- bleeding
- Sézary syndrome
- psoriasis
- lung adenocarcinoma
- lung adenocarcinoma formation
- neutrophilia
- Huntington disease
role in cell
- activation in
- phosphorylation in
- expression in
- cell viability
- apoptosis
- degradation in
- proliferation
- formation in
- generation in
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- cytosol
- sarcoplasm
- sarcolemma
- membrane rafts
- perikaryon
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CFLAR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- apoptotic signaling pathway
- regulation of necroptosis
- execution phase of apoptosis
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of neuron apoptotic process
- skeletal muscle tissue regeneration
- cellular response to insulin stimulus
- wound healing
- cellular response to estradiol stimulus
- apoptotic process
- cellular response to nitric oxide
- positive regulation of neuron projection development
- response to testosterone stimulus
- cellular response to hypoxia
- positive regulation of glomerular mesangial cell proliferation
- skeletal muscle atrophy
- neuron differentiation
- keratinocyte differentiation
- erythrocyte differentiation
- negative regulation of apoptotic process
- skeletal muscle tissue development
- positive regulation of ERK1 and ERK2 cascade
- cellular response to epidermal growth factor stimulus
- proteolysis
- negative regulation of extrinsic apoptotic signaling pathway
- negative regulation of cardiac muscle cell apoptotic process
- skeletal myofibril assembly
- cellular response to dexamethasone stimulus
- positive regulation of hepatocyte proliferation
- regulation of satellite cell proliferation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- death-inducing signaling complex
- CD95 death-inducing signaling complex
Molecular Function
What the gene product does at the molecular level
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway
- cysteine-type endopeptidase activity involved in execution phase of apoptosis
- protein binding
- death receptor binding
- enzyme activator activity
- protease binding