LTK

LTK Gene Summary

The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Details

Type
Protein Coding
Official Symbol
LTK
Official Name
leukocyte receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6721]
Ensembl ID
ENSG00000062524
Bio databases IDs NCBI: 4058 Ensembl: ENSG00000062524
Aliases leukocyte receptor tyrosine kinase
Synonyms
leukocyte receptor tyrosine kinase,leukocyte tyrosine kinase,TYK1
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • extracellular domain
  • Protein kinase (unclassified specificity)
  • protein kinase
  • YXXM motif
  • Protein tyrosine and serine/threonine kinase
  • protein binding
  • protein-tyrosine kinase
  • Protein kinase domain
  • kinase
  • Serine/Threonine protein kinases, catalytic domain
  • Protein Kinases, catalytic domain
  • cytoplasmic domain
  • transmembrane receptor protein tyrosine kinase
  • transmembrane domain
  • intracellular domain
  • receptor signaling protein tyrosine kinase activator
  • Tyrosine kinase, catalytic domain

Pathways

Biological processes and signaling networks where the LTK gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • PTPN1
  • GOPC
  • RAB1B
  • MACROH2A1
  • RACK1
  • DDX39B
  • DSG2
  • RAF1
  • USP9X
  • GORASP2
disease
  • Parkinson disease
  • non-insulin-dependent diabetes mellitus
  • advanced lung squamous cell carcinoma
  • metastatic non-small cell lung cancer
  • advanced large cell lung carcinoma
  • advanced non-small cell lung cancer
  • non-small cell lung cancer
  • metastatic lung adenocarcinoma
  • ALK rearrangement positive non-small cell lung cancer
  • latent tuberculosis
regulated by
  • doxorubicin
  • MYCN
  • ALKAL2
  • selumetinib
  • KLF3
  • ENV
  • CXCL12
  • ALKAL1
  • METTL3
  • KMT2D
regulates
  • MAPK
  • AKT
  • CBL
  • RAC
  • WAS
  • F Actin
  • IGF1R
  • NPPA
  • NFAT (family)
  • SHC1
role in cell
  • expression in
  • phosphorylation in
  • proliferation
  • activation in
  • apoptosis
  • migration
  • quantity
  • polarization
  • development
  • response by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane
  • Endoplasmic Reticulum
  • cytosol
  • endoplasmic reticulum membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the LTK gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • cell proliferation
  • multicellular organismal development
  • signal transduction
  • peptidyl-tyrosine autophosphorylation
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • regulation of neuron differentiation
  • protein phosphorylation
  • regulation of cell proliferation
  • cellular response to retinoic acid
  • negative regulation of apoptotic process
  • positive regulation of cardiac muscle cell apoptotic process
  • positive regulation of kinase activity
  • positive regulation of neuron projection development
  • positive regulation of protein kinase B signaling cascade

CELLULAR COMPONENT

Where in the cell the gene product is active
  • membrane
  • receptor complex
  • plasma membrane

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • ATP binding
  • protein tyrosine kinase activity
  • protein binding
  • transmembrane receptor protein tyrosine kinase activity
  • protein kinase activity
  • receptor signaling protein tyrosine kinase activator activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.