GLI2
GLI2 Gene Summary
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GLI2 |
| Official Name | GLI family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:4318] |
| Ensembl ID | ENSG00000074047 |
| Bio databases IDs | |
| Aliases | GLI family zinc finger 2, tax-responsive element-2 holding protein, tax helper protein 1, tax helper protein 2 |
| Synonyms | CJS,GLI family zinc finger 2,GLI-Kruppel family member GLI2,HPE9,PHS2,THP1,THP2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 14-3-3 binding domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- nucleic acid binding
- transcription activation domain
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- androgen receptor binding domain
- transcription repression domain
- zinc ion binding
- processing determinant domain
- double-stranded DNA binding
- Zinc-finger double domain
- SYGH motif
- zinc finger domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the GLI2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- GCM1
- FOXA2
- SUFU
- CREB1
- SKI
- SMAD1
- RUNX2
- IL6R
- GLI2
- HDAC1
disease
- neoplasia
- Crohn disease
- epithelial cancer
- epithelial neoplasia
- cancer
- ulcerative colitis
- edema
- benign neoplasia
- prostatic carcinoma
- prostate cancer
regulated by
- HAVCR1
- carbon tetrachloride
- TP53
- SPOP
- SHH
- linoleic acid
- cisplatin
- RYBP
- TET3
- TET1
regulates
- TP53
- JUNB
- SPP1
- IL1B
- TNF
- RET
- ITGB1
- IL6
- Ccl3
- Ccl4
role in cell
- apoptosis
- quantity
- proliferation
- cell death
- formation
- signaling in
- killing
- activation in
- growth
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- motile cilia
- ciliary tip
- Cytoplasm
- cilia
- cellular membrane
- basal bodies
- centrosome
- axonemes
- cytosol
- nucleoplasm
- nucleoli
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GLI2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of T cell differentiation in thymus
- ventral spinal cord development
- smoothened signaling pathway involved in ventral spinal cord interneuron specification
- axon guidance
- odontogenesis of dentin-containing tooth
- positive regulation of DNA replication
- spinal cord dorsal/ventral patterning
- branching morphogenesis of a tube
- positive regulation of transcription from RNA polymerase II promoter
- proximal/distal pattern formation
- cerebellar cortex morphogenesis
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- skeletal system development
- embryonic digestive tract development
- kidney development
- positive regulation of transcription, DNA-dependent
- hindbrain development
- lung development
- floor plate formation
- tube development
- smoothened signaling pathway
- regulation of transcription, DNA-dependent
- pattern specification process
- developmental growth
- spinal cord ventral commissure morphogenesis
- neuron development
- hindgut morphogenesis
- osteoblast development
- regulation of transcription from RNA polymerase II promoter
- pituitary gland development
- ventral midline development
- mammary gland development
- hair follicle morphogenesis
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cilium
- cytosol
- nucleolus
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- zinc ion binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity