TP73
TP73 Gene Summary
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | TP73 |
| Official Name | tumor protein p73 [Source:HGNC Symbol;Acc:HGNC:12003] |
| Ensembl ID | ENSG00000078900 |
| Bio databases IDs | |
| Aliases | tumor protein p73 |
| Synonyms | CILD47,P73,p73RhoGAP,transformation related protein 73,Trp73,tumor protein p73,tumour protein p73 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- regulatory domain
- SAM domain
- homo-oligomerization domain
- transcription activation domain
- transcription factor binding
- P53 DNA-binding domain
- identical protein binding
- proline rich domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Sterile alpha motif
- SAM domain (Sterile alpha motif)
- Pka phosphorylation site
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- acetylation site
- protein kinase binding
- nuclear export signal
- tetramerization domain
- DNA binding domain
- nucleic acid binding
- oligomerization domain
- P53 tetramerization motif
- SAM (Sterile alpha motif )
- protein binding
- p53 binding
- sequence-specific DNA binding
- proline tyrosine motif
- DNA binding
- minimal transactivation domain
- double-stranded DNA binding
- PXXP motif
- C-terminal oligomerization domain
- CAD domain
- transcription factor activity
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the TP73 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- POU4F1
- PRKAA1
- E2F1
- EP300
- CDKN1A
- HDAC1
- AGO2
- TP63
- DDB1
- TP53BP2
disease
- diabetes mellitus
- neoplasia
- Huntington disease
- Alzheimer disease
- cancer
- breast adenocarcinoma
- breast cancer
- survival
- lung adenocarcinoma formation
- urothelial bladder carcinoma
regulated by
- hydrogen peroxide
- IFNG
- APP
- HeLa cells
- PSEN1
- cisplatin
- metformin
- indomethacin
- HRAS
- TP53
regulates
- IL1B
- MAPK1
- reactive oxygen species
- CASP3
- AKT
- VEGF
- TH
- NFkB (complex)
- CDKN1A
- PROCR
role in cell
- activation in
- binding in
- migration
- apoptosis
- molecular cleavage in
- degeneration
- expression in
- proliferation
- induction in
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- nuclear matrix fraction
- cell junction
- intracellular membrane-bounded organelle
- Cytoplasm
- intracellular space
- perinuclear region
- Plasma Membrane
- basal bodies
- centrosome
- Golgi Apparatus
- Mitochondria
- cytosol
- nucleoplasm
- outer nuclear membrane
- nuclear bodies
- nuclear speckles
- nuclear lamina
- neurites
- chromatin
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TP73 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of cardiac muscle cell proliferation
- negative regulation of neuron differentiation
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- DNA damage response, signal transduction resulting in induction of apoptosis
- mismatch repair
- response to xenobiotic stimulus
- positive regulation of MAPK cascade
- positive regulation of transcription from RNA polymerase II promoter
- response to DNA damage stimulus
- regulation of mitotic cell cycle
- positive regulation of oligodendrocyte differentiation
- regulation of transcription from RNA polymerase II promoter
- kidney development
- positive regulation of transcription, DNA-dependent
- protein tetramerization
- positive regulation of apoptotic process
- regulation of gene expression
- regulation of cell cycle
- response to organic nitrogen
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- cell junction
- cytosol
- Golgi apparatus
- chromatin
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- p53 binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity