PGR
PGR Gene Summary
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | PGR |
| Official Name | progesterone receptor [Source:HGNC Symbol;Acc:HGNC:8910] |
| Ensembl ID | ENSG00000082175 |
| Bio databases IDs | |
| Aliases | progesterone receptor |
| Synonyms | 9930019P03Rik,BB114106,LOC360433,NR3C3,Pgrb,PR,PR beta,progesterone receptor,Progesterone receptor A,PR β |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sumoylation motif
- steroid hormone receptor
- RNA recognition motif
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- transcription activation domain
- transcription factor binding
- AF-2 transcription activation domain
- identical protein binding
- proline rich domain
- Sh3 domain binding motif
- hormone binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- nuclear receptor ligand binding domain
- AF-1 domain
- ligand-binding domain
- ligand-dependent nuclear receptor
- hPR hormone binding domain
- progesterone receptor B-upstream sequence
- AF-3 domain (of nuclear hormone receptor)
- Progesterone receptor
- proline/glutamine rich region
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- hormone binding
- DNA binding domain
- nucleic acid binding
- nuclear localization sequence
- enzyme binding
- helical domain
- protein binding
- receptor binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- steroid binding
- ATPase binding
- cdk2 phosphorylation site
- double-stranded DNA binding
- hinge domain
- zinc finger domain
- Ligand-binding domain of nuclear hormone receptor
- estrogen receptor binding domain
- C-terminal extension
Pathways
Biological processes and signaling networks where the PGR gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PGR
- XRCC5
- NR3C1
- NR3C2
- SUMO1
- SP1
- CEBPB
- NCOA2
- KLF9
- PIAS2
disease
- hypertension
- urinary tract infection
- mammary neoplasm
- uterine sarcoma
- endometrial carcinoma
- cancer
- neoplasia
- non-insulin-dependent diabetes mellitus
- invasive breast cancer
- metastatic invasive breast cancer
regulated by
- actinomycin D
- IGF1
- tetradecanoylphorbol acetate
- cycloheximide
- forskolin
- lipopolysaccharide
- sodium arsenite
- EGF
- heavy metal
- beta-estradiol
regulates
- ERK
- ESR1
- reporter gene
- synthetic promoter
- CXCL8
- RUNX1
- VEGF
- TNF
- IL6
- HSPG2
role in cell
- quantity
- cell viability
- migration
- number
- morphology
- expression in
- production in
- survival
- apoptosis
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- Plasma Membrane
- Mitochondria
- cytosol
- nuclear foci
- nucleoplasm
- dendritic spines
- cell membrane leading edge
- chromatin
- perikaryon
- axons
- dendrites
- axon terminals
- plasma
- lamellipodia
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PGR gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- signal transduction
- glandular epithelial cell maturation
- paracrine signaling
- cell-cell signaling
- regulation of transcription, DNA-dependent
- tertiary branching involved in mammary gland duct morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of phosphorylation
- regulation of transcription from RNA polymerase II promoter
- ovulation from ovarian follicle
- lung alveolus development
- negative regulation of gene expression
- intracellular steroid hormone receptor signaling pathway
- positive regulation of gene expression
- progesterone receptor signaling pathway
- regulation of epithelial cell proliferation
- maintenance of protein location in nucleus
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytosol
- mitochondrial outer membrane
- chromatin
- plasma membrane
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- estrogen response element binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- steroid binding
- transcription coactivator binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- G-protein coupled receptor activity
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- steroid hormone receptor activity
- ATPase binding
- enzyme binding