CDC6
CDC6 Gene Summary
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CDC6 |
| Official Name | cell division cycle 6 [Source:HGNC Symbol;Acc:HGNC:1744] |
| Ensembl ID | ENSG00000094804 |
| Bio databases IDs | |
| Aliases | cell division cycle 6 |
| Synonyms | CDC18L,Cdc6-related,cell division cycle 6,HsCDC18,HsCDC6,MGORS5,p62(cdc6) |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotide binding
- AAA ATPase domain
- protein kinase binding
- walker type B motif
- orc1/cdc6 family replication initiation protein
- walker type A motif
- chromatin binding
- cyclin recognition motif
- protein binding
- phosphorylation site
- AAA domain
- ATPase family associated with various cellular activities (AAA)
- kinase binding
- ATPase domain
- Caspase 3 cleavage site
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- Cdc6 winged-helix domain
- CDC6, C terminal winged helix domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the CDC6 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- AR
- STING1
- CDK1
- histone H4
- GRWD1
- CCNF
- CDC20
- PCDHB11
- USP24
- TNFRSF10A
disease
- small cell lung cancer
- neoplasia
- epithelial neoplasia
- epithelial cancer
- cancer
- prostatic adenocarcinoma
- prostate cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- hepatocellular carcinoma
regulated by
- cycloheximide
- TP53
- CASP3
- YAP1
- LMCD1
- 26S proteasome
- CUL4B
- CCND1
- TNF
- CG
regulates
- BCL2
- CASP3
- TP53
- MYC
- AKT
- adenosine triphosphate
- CDH1
- ATR
- CDC6
- ATM
role in cell
- quantity
- binding
- proliferation
- binding in
- expression in
- damage in
- cell death
- growth
- apoptosis
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- spindle apparatus
- Cytoplasm
- cytoplasmic bridges
- cytosol
- nucleoplasm
- spindle pole
- central spindle
- mitotic spindle
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CDC6 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
- regulation of mitotic metaphase/anaphase transition
- negative regulation of cell proliferation
- traversing start control point of mitotic cell cycle
- negative regulation of DNA replication
- regulation of cyclin-dependent protein kinase activity
- cell division
- positive regulation of chromosome segregation
- DNA replication checkpoint
- positive regulation of fibroblast proliferation
- positive regulation of cytokinesis
- mitotic cell cycle DNA replication checkpoint
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- spindle midzone
- mitotic spindle
- cytoplasm
- spindle pole
- cytosol
- nucleolus
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- nucleotide binding
- ATPase activity
- DNA replication origin binding
- ATP binding
- protein binding
- kinase binding