HMOX1
HMOX1 Gene Summary
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HMOX1 |
| Official Name | heme oxygenase 1 [Source:HGNC Symbol;Acc:HGNC:5013] |
| Ensembl ID | ENSG00000100292 |
| Bio databases IDs | |
| Aliases | heme oxygenase 1 |
| Synonyms | bK286B10,D8Wsu38e,haemox,HEME OXYGENASE,Heme oxygenase 1,HEME OXYGENASE (DECYCLIZING) 1,Hemox,Heox,HEOXG,HMOX,HMOX1D,HO-1,HSP32,LOC103694288 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipase D
- membrane-association domain
- nuclear localization sequence
- enzyme binding
- enzyme
- protein binding
- heme binding
- identical protein binding
- heme oxygenase
- heme oxygenase (decyclizing)
- reduced flavin or flavoprotein:oxygen oxidoreductase
- protein homodimerization
- structural molecule
Pathways
Biological processes and signaling networks where the HMOX1 gene plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Antioxidant Action of Vitamin C
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Docosahexaenoic Acid (DHA) Signaling
- Endothelin-1 Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Gαq Signaling
- HIF1α Signaling
- IL-10 Signaling
- IL-8 Signaling
- Iron homeostasis signaling pathway
- mTOR Signaling
- Neuroinflammation Signaling Pathway
- NRF2-mediated Oxidative Stress Response
- Pancreatic Adenocarcinoma Signaling
- Phagosome Formation
- Serotonin Receptor Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- STING1
- SQSTM1
- LMNA
- CD79A
- Adaptor protein 2
- adaptor protein-2
- SIRT1
- TIAL1
- RNF4
- let-7a-5p (and other miRNAs w/seed GAGGUAG)
disease
- neoplasia
- metastasis
- tuberous sclerosis complex
- cancer
- perivascular fibrosis
- hepatic steatosis
- osteoporosis
- rheumatoid arthritis
- asthma
- retinal degeneration
regulated by
- LCN2
- APP
- PML
- glutathione
- tetrachlorodibenzodioxin
- CEBPA
- Escherichia coli O157:H7 EDL933
- boric acid
- TSC2
- NFE2L2
regulates
- p38 MAPK
- IL1B
- ERK1/2
- PCNA
- ALT
- CDKN1A
- MMP9
- CCL2
- ACTA2
- GOT
role in cell
- phosphorylation in
- proliferation
- production in
- expression in
- invasion by
- cell death
- cell viability
- degradation in
- migration
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
- microsome
- caveolae
- mitochondrial outer membrane
- nucleoplasm
- neurites
- smooth endoplasmatic reticulum
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the HMOX1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- multicellular organismal iron ion homeostasis
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of angiogenesis
- positive regulation of cell migration involved in sprouting angiogenesis
- heme oxidation
- positive regulation of angiogenesis
- cellular iron ion homeostasis
- positive regulation of smooth muscle cell proliferation
- response to oxidative stress
- cellular response to heat
- angiogenesis
- cellular response to cadmium ion
- negative regulation of smooth muscle cell proliferation
- positive regulation of chemokine production
- macroautophagy
- intracellular signal transduction
- low-density lipoprotein particle clearance
- cellular response to cisplatin
- positive regulation of macroautophagy
- erythrocyte homeostasis
- heme catabolic process
- response to nicotine
- response to hydrogen peroxide
- regulation of transcription from RNA polymerase II promoter
- wound healing involved in inflammatory response
- negative regulation of leukocyte migration
- smooth muscle hyperplasia
- cellular response to arsenic-containing substance
- endothelial cell proliferation
- negative regulation of macroautophagy
CELLULAR COMPONENT
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- extracellular space
- perinuclear region of cytoplasm
- membrane
- cytosol
- endoplasmic reticulum
- mitochondrial outer membrane
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- metal ion binding
- heme oxygenase (decyclizing) activity
- structural molecule activity
- heme binding
- enzyme binding