GATA3
GATA3 Gene Summary
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
Details
| Type | Protein Coding |
| Official Symbol | GATA3 |
| Official Name | GATA binding protein 3 [Source:HGNC Symbol;Acc:HGNC:4172] |
| Ensembl ID | ENSG00000107485 |
| Bio databases IDs | |
| Aliases | GATA binding protein 3 |
| Synonyms | GATA binding protein 3,HDR,HDRS,jal |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- zinc finger DNA binding domain
- transcription regulator
- DNA binding domain
- nucleic acid binding
- transcription activation domain
- enzyme binding
- transcription factor binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- interleukin-2 receptor binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- carboxy finger domain
- zinc finger binding to DNA consensus sequence [AT]GATA[AG]
- Pka phosphorylation site
- zinc finger domain
- transcription factor activity
- ZnF_GATA
- amino finger domain
Pathways
Biological processes and signaling networks where the GATA3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CAPN2
- FOS
- FOXP3
- TFAP4
- LCK
- ZMYM2
- CD3E
- ZFPM2
- DDB1
- NR2C1
disease
- epithelial cancer
- systemic lupus erythematosus
- multiple sclerosis
- neoplasia
- atopic dermatitis
- metastasis
- organismal death
- HDR syndrome
- breast carcinoma
- colorectal carcinoma
regulated by
- dexamethasone
- GATA3
- AICAR
- STAT6
- cycloheximide
- TGFB1
- CTNNB1
- TNFSF10
- concanavalin a
- TBX21
regulates
- CCR2
- FOS
- KIT
- IL17A
- IL6
- IL2
- IL10
- IFNG
- TGF beta
- IgG1
role in cell
- proliferation
- expression in
- activation in
- growth
- adhesion
- migration
- production in
- apoptosis
- quantity
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GATA3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- response to estrogen stimulus
- male gonad development
- embryonic hemopoiesis
- post-embryonic development
- axon guidance
- lens development in camera-type eye
- immune system development
- sympathetic nervous system development
- inflammatory response
- negative regulation of transcription, DNA-dependent
- in utero embryonic development
- positive regulation of transcription, DNA-dependent
- kidney development
- cellular response to BMP stimulus
- mesonephros development
- humoral immune response
- positive regulation of ureteric bud formation
- negative regulation of endothelial cell apoptotic process
- negative regulation of interferon-gamma production
- cell fate determination
- ureter maturation
- regulation of establishment of cell polarity
- mesenchymal to epithelial transition
- aortic valve morphogenesis
- negative regulation of inflammatory response
- anatomical structure formation involved in morphogenesis
- norepinephrine biosynthetic process
- positive regulation of signal transduction
- regulation of nephron tubule epithelial cell differentiation
- cardiac right ventricle morphogenesis
- nephric duct formation
- nephric duct morphogenesis
- positive regulation of protein kinase B signaling cascade
- cell proliferation
- negative regulation of cell proliferation
- negative regulation of cell cycle
- anatomical structure morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- regulation of neuron apoptotic process
- thymus development
- neuron migration
- protein kinase B signaling cascade
- negative regulation of interleukin-2 production
- positive regulation of endothelial cell migration
- T cell receptor signaling pathway
- parathyroid hormone secretion
- mast cell differentiation
- ventricular septum development
- defense response
- parathyroid gland development
- ureter morphogenesis
- negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
- cell fate commitment
- negative regulation of cell motility
- regulation of cytokine production
- transcription from RNA polymerase II promoter
- positive regulation of transcription regulatory region DNA binding
- regulation of neuron projection development
- positive regulation of T-helper 2 cell cytokine production
- macrophage differentiation
- embryonic organ development
- pharyngeal system development
- pro-T cell differentiation
- ureteric bud formation
- T cell differentiation
- negative regulation of cell proliferation involved in mesonephros development
- T-helper 2 cell differentiation
- thymic T cell selection
- erythrocyte differentiation
- regulation of epithelial cell differentiation
- positive regulation of T cell differentiation
- inner ear morphogenesis
- regulation of cellular response to X-ray
- positive regulation of interleukin-4 production
- cartilage development
- negative regulation of mammary gland epithelial cell proliferation
- positive regulation of interleukin-5 production
- uterus development
- regulation of T-helper cell differentiation
- response to virus
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of epithelial to mesenchymal transition
- negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
- cellular response to interleukin-4
- canonical Wnt receptor signaling pathway
- cellular response to tumor necrosis factor
- positive regulation of thyroid hormone generation
- otic vesicle development
- cellular response to interferon-alpha
- signal transduction
- cell maturation
- TOR signaling cascade
- developmental growth
- positive regulation of interleukin-13 production
- innate immune response
- ear development
- lymphocyte migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- zinc ion binding
- HMG box domain binding
- identical protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- interleukin-2 receptor binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- transcription coactivator binding
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- E-box binding