CREB1
CREB1 Gene Summary
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | CREB1 |
| Official Name | cAMP responsive element binding protein 1 [Source:HGNC Symbol;Acc:HGNC:2345] |
| Ensembl ID | ENSG00000118260 |
| Bio databases IDs | |
| Aliases | cAMP responsive element binding protein 1 |
| Synonyms | 2310001E10Rik,3526402H21RIK,CAMP RESPONSE ELEMENT binding protein 1,cAMP responsive element binding protein 1,Cbp,CREB |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Hsp70 protein binding
- transcription activation domain
- transcription factor binding
- leucine zipper domain
- glutamine-rich domain
- identical protein binding
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- P-box
- pKID domain
- Pka phosphorylation site
- basic domain
- bZIP
- histone acetyltransferase binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- dimerization domain
- kinase interacting domain
- DNA binding domain
- nucleic acid binding
- enzyme binding
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- Q2 domain
- double-stranded DNA binding
- serine threonine rich domain
- transcription factor activity
- basic region leucin zipper
- hydrophobic domain
Pathways
Biological processes and signaling networks where the CREB1 gene plays a role, providing insight into its function and relevance in health or disease.
- ATM Signaling
- BMP signaling pathway
- Corticotropin Releasing Hormone Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- ERK5 Signaling
- Estrogen-Dependent Breast Cancer Signaling
- FGF Signaling
- GDNF Family Ligand-Receptor Interactions
- Glucocorticoid Receptor Signaling
- Gαs Signaling
- Hypoxia Signaling in the Cardiovascular System
- IL-10 Signaling
- LPS-stimulated MAPK Signaling
- Melanocyte Development and Pigmentation Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Neuroprotective Role of THOP1 in Alzheimer's Disease
- Neurotrophin/TRK Signaling
- NGF Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Relaxin Signaling
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- HLA-G
- IL2
- CREM
- SST
- LORICRIN
- PRKAR2B
- cyclin A
- CREBBP
- PER1
- MAB21L2
disease
- edema
- cardiac fibrosis
- major depression
- depressive disorder
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- diabetic nephropathy
- motor dysfunction
regulated by
- quercetin
- L-glutamic acid
- Ca2+
- PRKG1
- TSH
- BAY K8644
- tetradecanoylphorbol acetate
- carbamylcholine
- CG
- norepinephrine
regulates
- IL6
- HMOX1
- IRF7
- histone H3
- IL1B
- HERPUD1
- D-glucose
- TNF
- SQSTM1
- cholesterol
role in cell
- expression in
- cell death
- proliferation
- accumulation in
- invasion by
- cell viability
- apoptosis
- activation in
- migration
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- basal bodies
- centrosome
- cytosol
- mitochondrial matrix
- nuclear foci
- nucleoplasm
- chromatin
- axons
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CREB1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- secretory granule organization
- regulation of cell size
- positive regulation of fat cell differentiation
- lactation
- response to xenobiotic stimulus
- protein phosphorylation
- positive regulation of transcription from RNA polymerase II promoter
- hormone secretion
- memory
- positive regulation of multicellular organism growth
- cellular response to zinc ion
- positive regulation of osteoclast differentiation
- positive regulation of transcription, DNA-dependent
- Type I pneumocyte differentiation
- axonogenesis
- positive regulation of cardiac muscle tissue development
- mRNA transcription from RNA polymerase II promoter
- lung saccule development
- signal transduction
- response to purine-containing compound
- positive regulation of hormone secretion
- circadian rhythm
- pituitary gland development
- regulation of transcription from RNA polymerase II promoter
- positive regulation of lipid biosynthetic process
- osteoclast differentiation
- cellular response to retinoic acid
- negative regulation of transcription by competitive promoter binding
- negative regulation of apoptotic process
- cellular response to hepatocyte growth factor stimulus
- response to glucagon stimulus
- protein stabilization
- cAMP-mediated signaling
- regulation of testosterone biosynthetic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- euchromatin
- chromatin
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- cAMP response element binding
- sequence-specific DNA binding transcription factor activity
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- enzyme binding