ABCG2
ABCG2 Gene Summary
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Details
| Type | Protein Coding |
| Official Symbol | ABCG2 |
| Official Name | ATP binding cassette subfamily G member 2 (Junior blood group) [Source:HGNC Symbol;Acc:HGNC:74] |
| Ensembl ID | ENSG00000118777 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily G member 2 (Junior blood group) |
| Synonyms | ABC15,ABCP,ATP binding cassette subfamily G member 2,ATP binding cassette subfamily G member 2 (JR blood group),ATP binding cassette subfamily G member 2 (Junior blood group),BCRP,BCRP1,BMDP,CD338,CDw338,CDw388,EST157481,GOUT1,MRX,MXR,MXR-1,UAQTL1,UAQTL3 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ABC-2 type transporter
- FeS assembly ATPase SufC
- ABC-2 family transporter protein
- efflux permease
- nitrate transport ATP-binding subunits C and D
- identical protein binding
- urate transporter
- heme ABC exporter, ATP-binding protein CcmA
- nucleotide-binding domain
- LPS export ABC transporter ATP-binding protein
- cytoskeletal protein binding
- xenobiotic-transporting ATPase
- nickel import ATP-binding protein NikE
- urea ABC transporter, ATP-binding protein UrtD
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPase activity, coupled to transmembrane movement of substances
- The Eye Pigment Precursor Transporter (EPP) Family protein
- lipoprotein releasing system, ATP-binding protein
- amide transporter
- catalytic domain
- protein binding
- biotin transporter
- organic anion transporter
- phosphorylation site
- cobalt transport protein ATP-binding subunit
- xenobiotic transporter
- transmembrane domain
- protein homodimerization
- sphingolipid transporter
- ABC transporter
- transporter
Pathways
Biological processes and signaling networks where the ABCG2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- EGFR
- MYO5C
- apixaban
- CIT
- CD44
- miR-520g-3p (and other miRNAs w/seed CAAAGUG)
- adenosine triphosphate
- CHMP4C
- CAPZA1
- SMAD3
disease
- epithelial cancer
- cancer
- dementia
- obesity
- acute myeloid leukemia
- gout
- non-insulin-dependent diabetes mellitus
- breast cancer
- liver cancer
- endometrial cancer
regulated by
- quercetin
- sulforafan
- norepinephrine
- L-glutamic acid
- APP
- lipopolysaccharide
- carbamylcholine
- paclitaxel
- diethylstilbestrol
- PSEN1
regulates
- glutathione
- L-glutamic acid
- D-glucose
- phosphatidylserine
- ERK
- beta-estradiol sulfate
- ABCG2
- Ko143
- apixaban
- bile salt conjugates
role in cell
- apoptosis
- proliferation
- accumulation in
- expression in
- differentiation
- survival
- quantity
- migration
- activation in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- intracellular compartment
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- vesicles
- lysosome
- Mitochondria
- plasma membrane extracellular face
- apical membrane
- Golgi stacks
- mitochondrial cristae
- nucleoplasm
- membrane rafts
- brush border
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ABCG2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- lipid transport
- riboflavin transport
- transmembrane transport
- transepithelial transport
- urate transport
- biotin transport
- organic anion transport
- urate metabolic process
- sphingolipid biosynthetic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- brush border membrane
- mitochondrial membrane
- membrane raft
- apical plasma membrane
- plasma membrane
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATPase activity
- xenobiotic transporter activity
- biotin transporter activity
- ATPase activity, coupled to transmembrane movement of substances
- identical protein binding
- protein homodimerization activity
- efflux transmembrane transporter activity
- urate transmembrane transporter activity
- xenobiotic-transporting ATPase activity
- organic anion transmembrane transporter activity
- sphingolipid transporter activity
- ATP binding
- protein binding
- riboflavin transporter activity